Supplement · Grade C

Resveratrol and medications.

Every documented pair, every citation. Below: 2 documented pairs grouped by mechanism.

Resveratrol is classified as a targeted supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.

Resveratrol is a polyphenol found in grape skin and red wine, sold mostly as the trans isomer, which is the only form with activity. In mice it extended lifespan by mimicking calorie restriction through the sirtuin pathway, and that animal data is genuinely compelling. Human trials have been disappointing in most outcomes. The likely reason is very rapid first-pass metabolism, so most of a supplemental dose may never reach tissue at meaningful levels, and sirtuin activation at these doses stays unproven in people. This is a Grade C compound, reserved for longevity goals in someone over 45 who already has the better-evidenced options in place. The interaction angle matters more than the benefit. Resveratrol inhibits CYP3A4, so it can raise levels of statins, calcium channel blockers and immunosuppressants, and it has a mild blood-thinning effect worth flagging on warfarin, aspirin or DOACs. It also shows oestrogenic activity at high doses, so it is excluded in hormone-sensitive cancers.

Below are the 2 documented pairs we have explicitly assessed for Resveratrol: 2 red. The pairs cluster around 1 mechanism: CYP3A4 inhibition. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.

Documented interactions

CYP3A4 inhibition

Red Ciclosporin

Resveratrol can slow how the body clears ciclosporin, which may push ciclosporin blood levels higher than intended. We treat this as a do-not-combine pair outside direct transplant-team supervision.

BNF: Ciclosporin

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Red Tacrolimus

Resveratrol can slow how the body clears tacrolimus, which may push tacrolimus blood levels higher than intended. We treat this as a do-not-combine pair outside direct transplant-team supervision.

BNF: Tacrolimus

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.