Resveratrol and medications.
Resveratrol is in the Distil database but is not recommended: it is graded for none of the goals we score, so a Distil report never adds it to a stack. The page below lists every medication we have explicitly assessed it against.
Resveratrol is a polyphenol found in grape skin and red wine, sold mostly as the trans isomer, which is the only form with activity. In mice it extended lifespan by mimicking calorie restriction through the sirtuin pathway, and that animal data is genuinely compelling. Human trials have been disappointing in most outcomes. The likely reason is very rapid first-pass metabolism, so most of a supplemental dose may never reach tissue at meaningful levels, and sirtuin activation at these doses stays unproven in people. This is a Grade C compound, reserved for longevity goals in someone over 45 who already has the better-evidenced options in place. The interaction angle matters more than the benefit. Resveratrol inhibits CYP3A4, so it can raise the blood levels of medicines cleared by that enzyme: statins, calcium channel blockers, and transplant immunosuppressants such as tacrolimus and ciclosporin. It can also change the levels of some HIV antiretrovirals. For these narrow-window medicines (transplant immunosuppressants and several antiretrovirals) it is best avoided without your transplant or HIV specialist's oversight, because even a small shift in drug level can cause harm. It also has a mild blood-thinning effect worth flagging on warfarin, aspirin or newer blood thinners (DOACs). It also shows oestrogenic activity at high doses, so it is excluded in hormone-sensitive cancers.
Below are the 25 documented pairs we have explicitly assessed for Resveratrol: 10 severe and 15 caution. The pairs cluster around 6 mechanisms: CYP-mediated metabolism, CYP3A4 inhibition, Additive anticoagulation, Additive antiplatelet effect, CYP1A2 induction, and CYP2C9 inhibition. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Last reviewed 27 August 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
CYP-mediated metabolism
Severe Does Resveratrol interact with Efavirenz?
Resveratrol supplements may shift efavirenz levels, and we cannot say reliably in which direction, so we treat this as a do-not-combine pair outside your HIV team's supervision. Too little efavirenz may let the virus become resistant to this whole family of HIV medicines, and too much tends to worsen the dizziness, vivid dreams and low mood it can cause. The small amounts in red wine and grapes are not the concern; concentrated supplements are, and no study has tested this combination in people.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
CYP3A4 inhibition
Severe Does Resveratrol interact with Ciclosporin?
Resveratrol can slow how the body clears ciclosporin, which may push ciclosporin blood levels higher than intended. We treat this as a do-not-combine pair outside direct transplant-team supervision.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Severe Does Resveratrol interact with Everolimus?
Resveratrol can slow how the body clears everolimus, which may push everolimus blood levels higher than intended. We treat this as a do-not-combine pair outside direct specialist supervision.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Severe Does Resveratrol interact with Sirolimus?
Resveratrol can slow how the body clears sirolimus, which may push sirolimus blood levels higher than intended. We treat this as a do-not-combine pair outside direct transplant-team supervision.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Severe Does Resveratrol interact with Tacrolimus?
Resveratrol can slow how the body clears tacrolimus, which may push tacrolimus blood levels higher than intended. We treat this as a do-not-combine pair outside direct transplant-team supervision.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Amiodarone?
Resveratrol can slow how the body clears amiodarone, which could raise amiodarone levels. Amiodarone is a heart-rhythm drug with a narrow safe range, so check with your cardiology team before taking resveratrol.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Carbamazepine?
Resveratrol can raise blood levels of carbamazepine by slowing how the body clears it, which may increase side effects such as dizziness, drowsiness, or unsteadiness. Carbamazepine has a narrow safe range, so tell your epilepsy or prescribing team before taking resveratrol.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Additive anticoagulation
Caution Does Resveratrol interact with Acenocoumarol?
Resveratrol can both slow how the body clears warfarin-type blood thinners like acenocoumarol and mildly thin the blood by reducing platelet clumping, which could push your INR up. Food amounts are not the concern; concentrated supplements are. If you take acenocoumarol, tell your anticoagulant clinic before starting resveratrol and watch for bruising or bleeding.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Warfarin sodium?
Resveratrol can act on warfarin in two ways: it can slow how the body clears warfarin and it can mildly thin the blood by reducing how platelets clump. Both could nudge your INR up and raise bleeding risk. The concern is with supplement doses, not the small amount in food. If you take warfarin, tell your anticoagulant clinic before starting resveratrol and expect closer INR checks at first.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Additive antiplatelet effect
Caution Does Resveratrol interact with Apixaban?
Resveratrol can mildly thin the blood by reducing platelet clumping, which could add to apixaban. Apixaban has no routine blood test to track this, so keep any resveratrol dose modest and tell your GP if you take both. The amount in food is not the concern.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Aspirin?
Resveratrol can mildly reduce how platelets clump, which adds to aspirin's blood-thinning effect and may slightly raise bleeding risk. The amount in food is not the concern; concentrated supplements are. If you take aspirin and use resveratrol supplements, mention it to your GP and watch for easy bruising or bleeding.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Clopidogrel?
Resveratrol can mildly reduce platelet clumping, which adds to clopidogrel's blood-thinning effect and may slightly raise bleeding risk. Concentrated supplements are the concern, not food amounts. If you take clopidogrel and use resveratrol, mention it to your GP and watch for unusual bruising or bleeding.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Dabigatran etexilate?
Resveratrol can mildly thin the blood by reducing platelet clumping, which could add to dabigatran. There is no routine blood test for dabigatran, so keep any resveratrol dose modest and tell your GP if you take both. Food amounts are not the concern.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Edoxaban?
Resveratrol can mildly thin the blood by reducing platelet clumping, which could add to edoxaban. There is no routine blood test for edoxaban, so keep any resveratrol dose modest and tell your GP if you take both. Food amounts are not the concern.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Rivaroxaban?
Resveratrol can mildly thin the blood by reducing platelet clumping, which could add to rivaroxaban. Rivaroxaban has no routine blood test to track this, so keep any resveratrol dose modest and tell your GP if you take both. Food amounts are not the concern.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Ticagrelor?
Resveratrol can mildly reduce platelet clumping, which adds to ticagrelor's blood-thinning effect and may slightly raise bleeding risk. Concentrated supplements are the concern. If you take ticagrelor and use resveratrol, mention it to your GP and watch for bruising or bleeding.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
CYP1A2 induction
Caution Does Resveratrol interact with Clozapine?
Resveratrol may speed up how the body clears clozapine, which could lower clozapine levels and reduce how well it works. Clozapine is carefully dose-managed, so do not change supplements without telling the team that monitors your clozapine.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Fezolinetant?
Resveratrol may speed up how the body clears fezolinetant, which could lower fezolinetant levels and make it less effective at controlling hot flushes. If you take fezolinetant for menopause symptoms, mention resveratrol to your prescriber rather than starting it on your own.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Resveratrol interact with Theophylline?
Resveratrol may speed up how the body clears theophylline, which could lower theophylline levels and reduce how well it controls your breathing. Theophylline has a narrow safe range, so tell your respiratory team before taking resveratrol rather than starting it on your own.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
CYP2C9 inhibition
Caution Does Resveratrol interact with Phenytoin?
Resveratrol can slow how the body clears phenytoin by acting on a liver enzyme (CYP2C9), which could raise phenytoin levels. Phenytoin has a narrow safe range and small rises can cause side effects, so tell your epilepsy team before taking resveratrol.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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