Supplements and Amiodarone.
Amiodarone, sold under the brand names Cordarone, Pacerone, Nexterone, is an antiarrhythmic: it stabilises cardiac rhythm by acting on cardiac ion channels or beta-adrenergic receptors.
Amiodarone is an antiarrhythmic agent, used in atrial fibrillation, atrial flutter, or specific ventricular arrhythmias. The Vaughan Williams classification splits the agents by predominant mechanism. Class I (sodium channel blockers, including flecainide and propafenone). Class II (beta-blockers, classified separately). Class III (potassium channel blockers, including amiodarone and sotalol). Class IV (the non-dihydropyridine CCBs). The clinical issue with supplement interactions is QT prolongation. Anything else extending QT (certain antibiotics, some antidepressants, occasional supplements) stacks on top, and the additive effect can be clinically significant. Amiodarone specifically is heavily CYP3A4 metabolised and a strong CYP inhibitor itself. That generates a long list of drug and supplement interactions. Omega-3 EPA plus DHA has been studied at higher doses with a small AF incidence signal (Gencer 2021 pooled trials), which matters specifically in this prescribing context.
Below are the 2 documented pairs we have explicitly assessed against Amiodarone in the Distil database: 1 red and 1 amber. The pairs cluster around 2 mechanisms: Additive iodine load (thyroid toxicity) and CYP3A4 inhibition. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive iodine load (thyroid toxicity)
Red Does Iodine interact with ?
Amiodarone is itself an enormous iodine load, and around one in five people taking it develop a thyroid problem because of that. Adding an iodine supplement on top increases that risk and is not advised. Do not take iodine while you are on amiodarone unless a specialist has specifically told you to.
Evidence: Supported by human study data.
CYP3A4 inhibition
Amber Does Resveratrol interact with ?
Resveratrol can slow how the body clears amiodarone, which could raise amiodarone levels. Amiodarone is a heart-rhythm drug with a narrow safe range, so check with your cardiology team before taking resveratrol.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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