Supplements and Amiodarone.
Amiodarone, sold under the brand names Cordarone, Pacerone, Nexterone, is an antiarrhythmic: it stabilises cardiac rhythm by acting on cardiac ion channels or beta-adrenergic receptors.
Amiodarone is an antiarrhythmic agent, used in atrial fibrillation, atrial flutter, or specific ventricular arrhythmias. The Vaughan Williams classification splits the agents by predominant mechanism. Class I (sodium channel blockers, including flecainide and propafenone). Class II (beta-blockers, classified separately). Class III (potassium channel blockers, including amiodarone and sotalol). Class IV (the non-dihydropyridine CCBs). The clinical issue with supplement interactions is QT prolongation. Anything else extending QT (certain antibiotics, some antidepressants, occasional supplements) stacks on top, and the additive effect can be clinically significant. Amiodarone specifically is heavily CYP3A4 metabolised and inhibits several drug-metabolising enzymes itself, which raises the levels of medicines such as warfarin and digoxin. That generates a long list of drug and supplement interactions. Omega-3 EPA plus DHA has been studied at higher doses with a small AF incidence signal (Gencer 2021 pooled trials), which matters specifically in this prescribing context. Because it is taken for a heart rhythm condition, a Distil report leaves out Panax ginseng, Bacopa, Huperzine A and Tongkat Ali for anyone on it, since each may affect heart rate or rhythm.
Below are the 6 documented pairs we have explicitly assessed against Amiodarone in the Distil database: 1 severe and 5 caution. The pairs cluster around 5 mechanisms: Additive iodine load (thyroid toxicity), Additive bradycardia (slowed heart rate), Additive QT prolongation (heart rhythm), CYP3A4 inhibition, and Narrow-therapeutic-index prescriber awareness. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 30 October 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive iodine load (thyroid toxicity)
Severe Does Iodine interact with Amiodarone?
Amiodarone is itself an enormous iodine load, and around one in five people taking it develop a thyroid problem because of that. Adding an iodine supplement on top increases that risk and is not advised. Do not take iodine while you are on amiodarone unless a specialist has specifically told you to.
Evidence: Supported by human study data.
Additive bradycardia (slowed heart rate)
Caution Does Huperzine A interact with Amiodarone?
Huperzine A works like some dementia medicines that can slow the heart rate, and amiodarone slows it too, so together they may make your pulse too slow and cause dizziness or fainting. With amiodarone, which is taken for a heart rhythm condition, it is safest not to take huperzine A unless your cardiologist agrees.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Additive QT prolongation (heart rhythm)
Caution Does Panax Ginseng interact with Amiodarone?
Amiodarone lengthens the QT interval, the heart's electrical recovery time, and in a small trial in healthy adults a dose of Panax ginseng lengthened it slightly too, so the two may add up. With amiodarone, which is taken for a heart rhythm condition, it is safest not to take Panax ginseng unless your cardiologist agrees.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
CYP3A4 inhibition
Caution Does Resveratrol interact with Amiodarone?
Resveratrol can slow how the body clears amiodarone, which could raise amiodarone levels. Amiodarone is a heart-rhythm drug with a narrow safe range, so check with your cardiology team before taking resveratrol.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Narrow-therapeutic-index prescriber awareness
Caution Does Bacopa Monnieri interact with Amiodarone?
Bacopa may slow the heart rate a little: in one 12-week trial, heart rate held steady on bacopa while it rose on placebo. The effect is small, but with amiodarone, which is taken for a heart rhythm condition, it is safest not to take bacopa unless your cardiologist agrees.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Tongkat Ali interact with Amiodarone?
One man developed atrial flutter, a fast abnormal heart rhythm, two days after starting tongkat ali, and it settled within a day of stopping. That is a single report, but with amiodarone, which is taken for a heart rhythm condition, it is safest not to take tongkat ali unless your cardiologist agrees.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 until 30 June 2027 · £79 from 1 July 2027.
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