Vitamin K2 and medications.
Vitamin K2 is not yet in the Distil recommendation database. It is not excluded on safety grounds; it has not yet been through our evidence review.
Vitamin K2 is a special case, and the reason it has no page of its own is not that we have overlooked it. We do recommend K2, as MK-7 at 100 to 200mcg, and it sits inside our Vitamin D3 + K2 entry rather than standing alone, because our position is that K2 belongs alongside D3 rather than on its own. Keeping the two together is also what keeps two safety rules attached to it: we drop the K2 half for anyone pregnant or breastfeeding, where there is no safety data for MK-7, and for anyone on warfarin or a similar vitamin-K-antagonist anticoagulant.
On its own merits the evidence is Grade C, meaning emerging rather than settled, and the detail is worth having. The mechanism is real and reliably engaged: every trial we hold that measured the relevant blood markers found MK-7 moving them. The outcomes have not followed as cleanly. Two trials in postmenopausal women disagree about bone density, and the larger and independent one, at double our top dose, found no difference in bone loss at the hip or anywhere else. The clearest test of the arterial-calcification idea gave MK-7 with vitamin D to 365 men for two years and found no effect on calcification, despite the blood markers moving as expected. And the fracture evidence often quoted for K2 comes from a different form at a pharmacological dose, roughly two hundred times a supplemental one, and some of that literature has since been retracted for fabricated data. So the honest description is a real mechanism, an unsettled benefit, and a form and dose that matter.
One interaction is worth flagging now. Vitamin K, both K1 and K2, opposes warfarin and the other vitamin-K-antagonist anticoagulants, so a steady or changing K2 intake can move your INR. If you take warfarin, K2 belongs in a conversation with your anticoagulant clinic rather than a self-started supplement.
We still hold the documented interactions for Vitamin K2, so the interactions checker covers it while the full evaluation is pending. Below are the 6 documented pairs we have explicitly assessed: 2 red and 4 green. Every call is cited to a clinical reference (PMID) or the British National Formulary.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Vitamin K pathway
Red Does Vitamin K2 interact with Acenocoumarol?
Vitamin K2 directly opposes acenocoumarol, which is a blood thinner that works by blocking vitamin K. Taking K2 can make acenocoumarol less effective and raise the risk of a clot, and changing your K2 intake can swing your INR test result. If you take acenocoumarol, do not start or stop vitamin K2 without your anticoagulant clinic's guidance, and keep your intake steady.
Evidence: Supported by human study data.
Red Does Vitamin K2 interact with Warfarin sodium?
Vitamin K is the nutrient warfarin works against. Supplementing vitamin K can blunt warfarin's effect and raise clot risk. Do not start, stop, or change vitamin K supplements without your anticoagulation clinic's guidance.
Evidence: Supported by human study data.
Other
Green Does Vitamin K2 interact with Apixaban?
Apixaban is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce apixaban's effect. If you are on apixaban rather than warfarin, this is a common worry that does not apply to you.
Evidence: Well established across multiple human studies or interaction references.
Green Does Vitamin K2 interact with Dabigatran etexilate?
Dabigatran is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce dabigatran's effect. If you are on dabigatran rather than warfarin, this is a common worry that does not apply to you.
Evidence: Well established across multiple human studies or interaction references.
Green Does Vitamin K2 interact with Edoxaban?
Edoxaban is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce edoxaban's effect. If you are on edoxaban rather than warfarin, this is a common worry that does not apply to you.
Evidence: Well established across multiple human studies or interaction references.
Green Does Vitamin K2 interact with Rivaroxaban?
Rivaroxaban is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce rivaroxaban's effect. If you are on rivaroxaban rather than warfarin, this is a common worry that does not apply to you.
Evidence: Well established across multiple human studies or interaction references.
What this page does not say. Leaving a compound out of our recommendations is not a verdict that it is useless for everyone. It is a statement about safety, evidence, or interaction load in the context Distil screens for. Discuss any supplement decision with whoever manages your prescriptions.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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