Vitamin K2 and medications.
Vitamin K2 is not yet in the Distil recommendation database. It is not excluded on safety grounds; it has not yet been through our evidence review.
Vitamin K2 is a special case. It has good evidence behind it, and it is not excluded on safety grounds. It simply has not yet been through the full Distil evidence review, so it is not in the recommendation database yet. A complete assessment will land in a future review pass.
One interaction is worth flagging now. Vitamin K, both K1 and K2, opposes warfarin and the other vitamin-K-antagonist anticoagulants, so a steady or changing K2 intake can move your INR. If you take warfarin, K2 belongs in a conversation with your anticoagulant clinic rather than a self-started supplement.
We still hold the documented interactions for Vitamin K2, so the interactions checker covers it while the full evaluation is pending. Below are the 6 documented pairs we have explicitly assessed: 2 red and 4 green. Every call is cited to a clinical reference (PMID) or the British National Formulary.
Documented interactions
Vitamin K pathway
Vitamin K2 directly opposes acenocoumarol, which is a blood thinner that works by blocking vitamin K. Taking K2 can make acenocoumarol less effective and raise the risk of a clot, and changing your K2 intake can swing your INR test result. If you take acenocoumarol, do not start or stop vitamin K2 without your anticoagulant clinic's guidance, and keep your intake steady.
Vitamin K is the nutrient warfarin works against. Supplementing vitamin K can blunt warfarin's effect and raise clot risk. Do not start, stop, or change vitamin K supplements without your anticoagulation clinic's guidance.
Other
Apixaban is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce apixaban's effect. If you are on apixaban rather than warfarin, this is a common worry that does not apply to you.
Dabigatran is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce dabigatran's effect. If you are on dabigatran rather than warfarin, this is a common worry that does not apply to you.
Edoxaban is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce edoxaban's effect. If you are on edoxaban rather than warfarin, this is a common worry that does not apply to you.
Rivaroxaban is not a warfarin-type blood thinner, so vitamin K does not work against it the way it works against warfarin. Vitamin K2 does not reduce rivaroxaban's effect. If you are on rivaroxaban rather than warfarin, this is a common worry that does not apply to you.
What this page does not say. Leaving a compound out of our recommendations is not a verdict that it is useless for everyone. It is a statement about safety, evidence, or interaction load in the context Distil screens for. Discuss any supplement decision with whoever manages your prescriptions.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyWant this checked across everything you take?
This page checks the pairs you enter. The personalised Distil report goes further:
- the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
- where your current routine may be leaving you short of your goals
- the evidence-backed compounds worth adding, and the ones worth dropping
It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.
See a real sample reportSomething missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.