Personal supplement reports
Supplement · Not recommended

Tongkat Ali and medications.

Tongkat Ali is in the Distil database but is not recommended: it is graded for none of the goals we score, so a Distil report never adds it to a stack. The page below lists every medication we have explicitly assessed it against.

Tongkat Ali, also called Eurycoma longifolia or longjack, is an extract of the plant's root. It has been listed as a novel food, not yet authorised, since 2008, a position that still applies in Great Britain, so it should not be on sale here as a supplement, although you may still see it sold, and the duty to follow that rule sits with the seller, not with you. It is widely sold for testosterone support, libido and stress, and the evidence behind those claims is thinner than the marketing suggests. The one randomised placebo-controlled trial we cite ran for four weeks in 63 moderately stressed adults and reported lower salivary cortisol and improved mood scores. It measured no sexual function or libido outcome at all, so the libido claim does not rest on it. That trial was funded by the manufacturer of the extract it tested, was run by the first author's own company, and counts an employee of that manufacturer among its authors. The other commonly cited study did normalise testosterone in men with diagnosed low testosterone, but it was open label with no placebo group, so it cannot separate the supplement from expectation, and it studied men who were already deficient rather than men with normal levels. Two practical cautions stand out. Unregulated products have been found contaminated with heavy metals. There is also a single 2025 case report of new-onset atrial flutter in an older man after starting it, so anyone with arrhythmia, palpitations or unexplained dizziness should avoid it pending more evidence and flag any heart symptoms to a GP. It may also interact with immunosuppressants.

Below are the 7 documented pairs we have explicitly assessed for Tongkat Ali: 7 caution. The pairs cluster around 3 mechanisms: Additive androgenic effect, Androgen-raising vs androgen-lowering (opposing), and Narrow-therapeutic-index prescriber awareness. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.

Documented interactions

Last reviewed 30 October 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.

Additive androgenic effect

Caution Does Tongkat Ali interact with Testosterone?

Tongkat ali can modestly raise the body's own testosterone, so taking it alongside prescribed testosterone may add to that effect. If you are on testosterone replacement, mention this supplement to the prescriber who monitors your levels before combining them.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 33559971 · PMID 37697053 · BNF: Testosterone

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Androgen-raising vs androgen-lowering (opposing)

Caution Does Tongkat Ali interact with Dutasteride?

Dutasteride works by lowering a potent form of testosterone. Tongkat ali tends to raise the body's testosterone, so in theory it could work against what dutasteride is doing. If you take dutasteride for prostate symptoms, it is worth discussing this supplement with your prescriber.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 33559971 · PMID 37697053 · BNF: Dutasteride

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Caution Does Tongkat Ali interact with Finasteride?

Finasteride works by lowering a potent form of testosterone. Tongkat ali tends to raise the body's testosterone, so in theory it could work against what finasteride is doing. If you take finasteride for hair loss or prostate symptoms, it is worth discussing this supplement with your prescriber.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 33559971 · PMID 37697053 · BNF: Finasteride

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Narrow-therapeutic-index prescriber awareness

Caution Does Tongkat Ali interact with Amiodarone?

One man developed atrial flutter, a fast abnormal heart rhythm, two days after starting tongkat ali, and it settled within a day of stopping. That is a single report, but with amiodarone, which is taken for a heart rhythm condition, it is safest not to take tongkat ali unless your cardiologist agrees.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 41080360 · BNF: Amiodarone

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Caution Does Tongkat Ali interact with Digoxin?

One man developed atrial flutter, a fast abnormal heart rhythm, two days after starting tongkat ali, and it settled within a day of stopping. That is a single report, but with digoxin, which is usually taken for atrial fibrillation or heart failure, it is safest not to take tongkat ali unless your cardiologist agrees.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 41080360 · BNF: Digoxin

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Caution Does Tongkat Ali interact with Flecainide acetate?

One man developed atrial flutter, a fast abnormal heart rhythm, two days after starting tongkat ali, and it settled within a day of stopping. That is a single report, but with flecainide, which is taken for a heart rhythm condition, it is safest not to take tongkat ali unless your cardiologist agrees.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 41080360 · BNF: Flecainide

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Caution Does Tongkat Ali interact with Sotalol hydrochloride?

One man developed atrial flutter, a fast abnormal heart rhythm, two days after starting tongkat ali, and it settled within a day of stopping. That is a single report, but with sotalol, which is taken for a heart rhythm condition, it is safest not to take tongkat ali unless your cardiologist agrees.

Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.

PMID 41080360 · BNF: Sotalol

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

Database last updated 2026-11-13. Free for everyone. No account, no paywall. · Browse coverage A-Z

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
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How the checker decides

Every result has a source

Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.

Four kinds of answer

Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.

  • Severe
  • Caution
  • No known interaction
  • Not yet assessed

Nothing in our data is not a clearance

When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.

Read the full methodology
The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

  • what your diet already covers, so you are not adding a capsule for something food is already handling
  • which evidence-graded compounds are worth considering for your goals, and which were considered but left out
  • what to keep, change or stop from what you already take, plus the order to introduce anything new
  • how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

£49 until 30 June 2027 · £79 from 1 July 2027.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.