Medication · other sex hormones

Supplements and Dutasteride.

Every documented pair, every citation. Below: 2 documented pairs grouped by mechanism.

Dutasteride, sold under the brand name Avodart, is a sex hormone preparation.

Dutasteride (brand names Avodart) sits in the Distil medication database. The BNF classifies it under "sex hormones". This means it sits outside the high-volume therapeutic classes (statins, PPIs, ACE inhibitors, SSRIs) where supplement-interaction surfaces are densely studied, and the published evidence base for specific supplement pairs is correspondingly thinner. Where interactions are documented in the Distil database, they are listed below with their clinical-reference citation; where pairs have not been explicitly assessed, the missing-item form at the bottom of the page routes them into our next curation pass. Anyone combining Dutasteride with a regular supplement stack benefits from explicit GP or pharmacist awareness rather than assuming no interaction exists by default.

Below are the 2 documented pairs we have explicitly assessed against Dutasteride in the Distil database: 2 amber. The pairs cluster around 2 mechanisms: Additive 5-alpha-reductase inhibition and Androgen-raising vs androgen-lowering (opposing). Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 14 June 2026. Each interaction below is assessed against PubMed-indexed evidence.

Additive 5-alpha-reductase inhibition

Amber Does Saw Palmetto interact with ?

Taking saw palmetto with dutasteride adds a second source of the same effect, because both act on the enzyme that converts testosterone to its more active form; this is usually not dangerous but is worth raising with your prescriber so your treatment can be looked at as a whole. Dutasteride lowers your PSA reading, which doctors track for prostate health; saw palmetto does not appear to lower PSA on its own, so it should not add to that effect or further mask the reading.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

PMID 15543614 · PMID 16985705 · PMID 12674456 · PMID 16467543 · PMID 21954478 · BNF: Dutasteride

Reviewer-flagged: awaiting clinical-reviewer sign-off.

Androgen-raising vs androgen-lowering (opposing)

Amber Does Tongkat Ali interact with ?

Dutasteride works by lowering a potent form of testosterone. Tongkat ali tends to raise the body's testosterone, so in theory it could work against what dutasteride is doing. If you take dutasteride for prostate symptoms, it is worth discussing this supplement with your prescriber.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

PMID 33559971 · PMID 37697053 · BNF: Dutasteride

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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where your current routine may be leaving you short of your goals
the evidence-graded compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 founder pricing while we earn our first reviews. The interactions check is one section of it, and you can read a real one in full before you decide.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.