Does Tongkat Ali interact with Testosterone?

Medication · other sex hormones

Supplements and Testosterone.

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Testosterone, sold under the brand names Tostran, Testogel, Testavan, Sustanon, Nebido, Restandol Testocaps, AndroGel, Depo-Testosterone, is a sex hormone preparation.

Testosterone (brand names Tostran, Testogel, Testavan, Sustanon, Nebido, Restandol Testocaps, AndroGel, Depo-Testosterone) sits at NHSBSA prescribing rank 205 in the 2024/25 PCA statistics. The BNF classifies it under "sex hormones". This means it sits outside the high-volume therapeutic classes (statins, PPIs, ACE inhibitors, SSRIs) where supplement-interaction surfaces are densely studied, and the published evidence base for specific supplement pairs is correspondingly thinner. Where interactions are documented in the Distil database, they are listed below with their clinical-reference citation; where pairs have not been explicitly assessed, the missing-item form at the bottom of the page routes them into our next curation pass. Anyone combining Testosterone with a regular supplement stack benefits from explicit GP or pharmacist awareness rather than assuming no interaction exists by default.

Below are the 1 documented pair we have explicitly assessed against Testosterone in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Additive androgenic effect. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.

Additive androgenic effect

Amber Does Tongkat Ali interact with ?

Tongkat ali can modestly raise the body's own testosterone, so taking it alongside prescribed testosterone may add to that effect. If you are on testosterone replacement, mention this supplement to the prescriber who monitors your levels before combining them.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

PMID 33559971 · PMID 37697053 · BNF: Testosterone

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.