Fisetin and medications.
Fisetin is classified as a targeted supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.
Fisetin is a plant flavonoid studied as a senolytic, meaning it may help clear senescent cells that accumulate with age. The evidence is Grade C and genuinely emerging. The foundational work, Yousefzadeh 2018 from the Mayo Clinic group, showed senolytic activity in aged mice and in human fat tissue tested outside the body, alongside antioxidant and neuroprotective effects. The honest limit is that human RCT data at supplement doses remains scarce as of 2026, so the biology is interesting but the supplement is running ahead of the clinical evidence. Dosing reflects the trial design rather than daily habit: it is pulsed, typically 100 to 500mg on two or three consecutive days once a month, not taken continuously. Long-term human safety data is limited, and stomach upset is the main reported issue. On interactions, fisetin may mildly reduce platelet clumping, so if you take an anticoagulant or antiplatelet medicine, tell your prescriber before starting a pulsed course and watch for bruising or bleeding. The concern is with a supplement course rather than the amounts in food. Beyond that, the realistic caution is that this is early-stage longevity territory, best reserved for people over 45 who understand it is exploratory.
Below are the 9 documented pairs we have explicitly assessed for Fisetin: 9 amber. The pairs cluster around 2 mechanisms: Additive anticoagulation and Additive antiplatelet effect. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive anticoagulation
Amber Does interact with Acenocoumarol?
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to vitamin-K-based blood thinners like acenocoumarol. The concern is with a high-dose fisetin course, not food amounts. If you take acenocoumarol, tell your anticoagulant clinic before starting a fisetin course and watch for bruising or bleeding.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Warfarin sodium?
Fisetin may mildly thin the blood by reducing how platelets clump, which could add to warfarin and nudge bleeding risk up. The concern is with a high-dose fisetin course, not the small amount in food. If you take warfarin, tell your anticoagulant clinic before starting a fisetin course and expect closer INR checks at first.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Additive antiplatelet effect
Amber Does interact with Apixaban?
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to apixaban. Apixaban has no routine blood test to track this, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Aspirin?
Fisetin may mildly reduce how platelets clump, which could add a little to aspirin's blood-thinning effect. This is most relevant during a high-dose fisetin course rather than the small amount in food. If you take aspirin and run a fisetin course, mention it to your GP and watch for easy bruising or bleeding.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Clopidogrel?
Fisetin may mildly reduce platelet clumping, which could add a little to clopidogrel's blood-thinning effect. This is most relevant during a high-dose fisetin course. If you take clopidogrel and run a fisetin course, mention it to your GP and watch for unusual bruising or bleeding.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Dabigatran etexilate?
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to dabigatran. There is no routine blood test for dabigatran, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Edoxaban?
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to edoxaban. There is no routine blood test for edoxaban, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Rivaroxaban?
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to rivaroxaban. Rivaroxaban has no routine blood test to track this, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Ticagrelor?
Fisetin may mildly reduce platelet clumping, which could add a little to ticagrelor's blood-thinning effect. This is most relevant during a high-dose fisetin course. If you take ticagrelor and run a fisetin course, mention it to your GP and watch for bruising or bleeding.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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