Fisetin and medications.
Fisetin is classified as a targeted supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.
Fisetin is a plant flavonoid studied as a senolytic, meaning it may help clear senescent cells that accumulate with age. The evidence is Grade C and genuinely emerging. The foundational work, Yousefzadeh 2018 from the Mayo Clinic group, showed senolytic activity in aged mice and in human fat tissue tested outside the body, alongside antioxidant and neuroprotective effects. The honest limit is that human RCT data at supplement doses remains scarce as of 2026, so the biology is interesting but the supplement is running ahead of the clinical evidence. Dosing reflects the trial design rather than daily habit: it is pulsed, typically 100 to 500mg on two or three consecutive days once a month, not taken continuously. Long-term human safety data is limited, and stomach upset is the main reported issue. The source notes no specific drug interactions, so the realistic caution is simply that this is early-stage longevity territory best reserved for people over 45 who understand it is exploratory.
Below are the 9 documented pairs we have explicitly assessed for Fisetin: 9 amber. The pairs cluster around 2 mechanisms: Additive anticoagulation and Additive antiplatelet effect. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Additive anticoagulation
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to vitamin-K-based blood thinners like acenocoumarol. The concern is with a high-dose fisetin course, not food amounts. If you take acenocoumarol, tell your anticoagulant clinic before starting a fisetin course and watch for bruising or bleeding.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly thin the blood by reducing how platelets clump, which could add to warfarin and nudge bleeding risk up. The concern is with a high-dose fisetin course, not the small amount in food. If you take warfarin, tell your anticoagulant clinic before starting a fisetin course and expect closer INR checks at first.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Additive antiplatelet effect
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to apixaban. Apixaban has no routine blood test to track this, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly reduce how platelets clump, which could add a little to aspirin's blood-thinning effect. This is most relevant during a high-dose fisetin course rather than the small amount in food. If you take aspirin and run a fisetin course, mention it to your GP and watch for easy bruising or bleeding.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly reduce platelet clumping, which could add a little to clopidogrel's blood-thinning effect. This is most relevant during a high-dose fisetin course. If you take clopidogrel and run a fisetin course, mention it to your GP and watch for unusual bruising or bleeding.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to dabigatran. There is no routine blood test for dabigatran, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to edoxaban. There is no routine blood test for edoxaban, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly thin the blood by reducing platelet clumping, which could add to rivaroxaban. Rivaroxaban has no routine blood test to track this, so keep any fisetin course modest and tell your GP if you take both. The amount in food is not the concern.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Fisetin may mildly reduce platelet clumping, which could add a little to ticagrelor's blood-thinning effect. This is most relevant during a high-dose fisetin course. If you take ticagrelor and run a fisetin course, mention it to your GP and watch for bruising or bleeding.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyWant this checked across everything you take?
This page checks the pairs you enter. The personalised Distil report goes further:
- the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
- where your current routine may be leaving you short of your goals
- the evidence-backed compounds worth adding, and the ones worth dropping
It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.
See a real sample reportSomething missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.