Urolithin A and medications.
Urolithin A is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.
Urolithin A is a compound your gut bacteria make from ellagic acid in pomegranate, walnuts and berries, but only around a third to 40 percent of people carry the bacteria to produce it, which is why a supplement can bypass that lottery. Typical doses are 500 to 1,000mg a day, and the clinical data sits with the Mitopure brand. Its mechanism is mitophagy: it helps clear out worn, dysfunctional mitochondria so fresh ones can take their place. The evidence is Grade B and still emerging, drawn from Phase I and II trials that reported activation of mitophagy markers and modest gains in muscle strength and endurance, including roughly a 12 percent strength improvement in one middle-aged group. Larger Phase III data may firm this up. No significant interactions showed up in the early trials and the safety profile has been clean. It works mechanistically alongside PQQ and CoQ10. Useful for muscle and ageing goals, but the human evidence is early.
We have not yet completed an explicit assessment of medications for Urolithin A in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Urolithin A alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.