Urolithin A and medications.
Urolithin A is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.
Urolithin A is a compound your gut bacteria make from ellagic acid in pomegranate, walnuts and berries, and only around a third to 40 percent of people carry the bacteria to produce it, which is the argument made for taking it as a supplement. In Great Britain urolithin A is not yet authorised as a novel food, so it should not be on sale here as a supplement, although you may still see it sold; the duty to follow that rule sits with the seller, not with you, and the application to authorise it is still in progress, so this may change. The trials used 500 to 1,000mg a day. Its proposed mechanism is mitophagy, meaning it may help clear away worn mitochondria so fresh ones can take their place, though that is a mechanism rather than a measured benefit. The trial picture is worth stating plainly, because it is less settled than the marketing suggests. Two randomised placebo-controlled trials missed their main pre-specified endpoints: peak power output in middle-aged adults in one, and both six-minute walk distance and muscle ATP production in adults aged 65 to 90 in the other. A third trial in highly trained distance runners concluded that it did not improve their performance. What has replicated is more modest and more specific: leg strength and resistance to muscle fatigue improved against placebo across several trials, including one independent trial with no involvement from the manufacturer. Readers should also know that most of the published research is authored by employees of the company that makes the branded form, which is why that independent trial carries disproportionate weight here. No significant interactions have been reported and the safety record has been clean across trials. On the evidence as it stands we do not recommend it for longevity, athletic performance or muscle building, and no trial in our records reports a muscle-mass or body-composition benefit, with no ageing outcome measured anywhere in them.
We have not yet completed an explicit assessment of medications for Urolithin A in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Urolithin A alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.