Supplement · Grade B

TUDCA and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

TUDCA is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

TUDCA is a water-soluble bile acid taken for liver and metabolic support, rated Grade B. It helps regulate bile flow and reduces a form of cellular stress in the endoplasmic reticulum, which is the proposed route behind its effects on cholestasis, fatty liver and insulin sensitivity. The evidence is promising but still developing: a small four-week trial improved hepatic and muscle insulin sensitivity by around 30 percent, and older bile-acid work supports liver enzyme and steatosis improvement, though sample sizes are small. Typical liver-support dosing is 500 to 750mg daily, with higher doses appearing in neurological research rather than standard supplement use. It often sits alongside silymarin for more advanced liver support, and is a useful addition in fatty liver with raised enzymes. There are no significant interactions at standard doses, but it must be avoided in complete biliary obstruction. It is expensive, so it is worth being clear about why you are taking it before committing.

We have not yet completed an explicit assessment of medications for TUDCA in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take TUDCA alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

Want this checked across everything you take?

This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

See a real sample report

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.