Phosphatidylcholine and medications.
Phosphatidylcholine is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.
Phosphatidylcholine is a phospholipid usually sourced from lecithin, including a sunflower form for those avoiding soy. It supplies choline for acetylcholine, which matters for memory, and it supports cell membrane structure and the way the liver handles fat and bile. The evidence is Grade B for both cognition and liver health. The clearer signal is in fatty liver: Loguercio 2012 combined it with silybin and vitamin E over twelve months and saw better liver enzymes, insulin resistance, and histology. A 2020 combination trial was more modest, with only a within-group enzyme change, so the liver case is real but not dramatic. Typical doses run 300 to 1,200mg daily, around 900mg for fatty liver support. It works alongside omega-3 DHA for brain membranes and complements silymarin for the liver. Side effects are mild and mostly digestive, with a fishy odour possible at very high doses. A practical option where both liver and memory are the aim.
We have not yet completed an explicit assessment of medications for Phosphatidylcholine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Phosphatidylcholine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.