Supplement · Grade B

Phosphatidylcholine and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Phosphatidylcholine is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

Phosphatidylcholine is a phospholipid usually sourced from lecithin, including a sunflower form for those avoiding soy. It supplies choline for acetylcholine, which matters for memory, and it supports cell membrane structure and the way the liver handles fat and bile. The evidence is Grade B for both cognition and liver health. The clearer signal is in fatty liver: Loguercio 2012 combined it with silybin and vitamin E over twelve months and saw better liver enzymes, insulin resistance, and histology. A 2020 combination trial was more modest, with only a within-group enzyme change, so the liver case is real but not dramatic. Typical doses run 300 to 1,200mg daily, around 900mg for fatty liver support. It works alongside omega-3 DHA for brain membranes and complements silymarin for the liver. Side effects are mild and mostly digestive, with a fishy odour possible at very high doses. A practical option where both liver and memory are the aim.

We have not yet completed an explicit assessment of medications for Phosphatidylcholine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Phosphatidylcholine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

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This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.