Supplement · Not recommended

Phosphatidylcholine and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Phosphatidylcholine is in the Distil database but is not recommended: it is graded for none of the goals we score, so a Distil report never adds it to a stack. The page below lists every medication we have explicitly assessed it against.

Phosphatidylcholine is a phospholipid usually sourced from lecithin, including a sunflower form for those avoiding soy. It supplies choline for acetylcholine and it is a structural part of cell membranes, which is the reason it is sold for memory and for the liver. We no longer recommend it for either, and it is worth saying plainly why. For memory, the only trial of the supplement in our records gave a single dose of 10 or 25 grams to college students and tested them ninety minutes later, and only the 25 gram dose did anything. That is between twenty and eighty times a normal supplement dose, and the dose closest to the normal range did nothing. The modern trials that look promising are of choline alfoscerate, a different compound, and the large positive study people cite is a survey of how much phosphatidylcholine men ate rather than a trial of taking it. For the liver, the well-known fatty liver result comes from Realsil, in which phosphatidylcholine is the carrier that gets silybin into the body, so the credit belongs to silybin, which has two meta-analyses of its own. The one trial in our records that put phosphatidylcholine into a mixture and compared it against a control found no difference between the groups. Typical doses run 300 to 1,200mg daily. Side effects are mild and mostly digestive, with a fishy odour possible at very high doses. If your aim is memory or liver support, citicoline and choline each carry their own evidence and are the better place to look.

We have not yet completed an explicit assessment of medications for Phosphatidylcholine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Phosphatidylcholine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

Database last updated 2026-11-13. Free for everyone. No account, no paywall. · Browse coverage A-Z

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How the checker decides

Every result has a source

Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.

Four kinds of answer

Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.

Severe
Caution
No known interaction
Not yet assessed

Nothing in our data is not a clearance

When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.

Read the full methodology

The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.