Supplement · Grade B

Passionflower and medications.

Every documented pair, every citation. Below: 3 documented pairs grouped by mechanism.

Passionflower is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

Below are the 3 documented pairs we have explicitly assessed for Passionflower: 3 amber. The pairs cluster around 1 mechanism: Additive CNS depression. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.

Documented interactions

Additive CNS depression

Amber Diazepam

Passionflower and diazepam both calm the nervous system through overlapping pathways. Combining them can mean stronger drowsiness and slower reactions. Akhondzadeh 2001 found passionflower comparable to oxazepam for generalised anxiety, which gives you a sense of the additive potential.

PMID 11679026 · BNF: Diazepam

Amber Lorazepam

Passionflower and lorazepam both calm the nervous system through overlapping pathways. Combining them can mean stronger drowsiness and slower reactions.

PMID 11679026 · BNF: Lorazepam

Amber Temazepam

Passionflower and temazepam both calm the nervous system through overlapping pathways. Combining them can mean stronger nocturnal sedation and a heavier morning hangover.

PMID 11679026 · BNF: Temazepam

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a comprehensive personalised stack reasoned against this same database, the Distil report is the next step up.