Supplements and Temazepam.
Temazepam, sold under the brand name Restoril, is a benzodiazepine: it potentiates GABA at the GABA-A receptor.
Below are the 5 documented pairs we have explicitly assessed against Temazepam in the Distil database: 1 red, 3 amber, and 1 green. The pairs cluster around 2 mechanisms: Additive CNS depression and Glucuronidation (no CYP interaction). Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Additive CNS depression
Kava and temazepam both depress the central nervous system, and kava is independently linked to liver injury. Combining the two raises the risk of excessive sedation, particularly with a hypnotic-strength benzodiazepine like temazepam. We treat this as a do-not-combine pair.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Ashwagandha can have a mild sedating effect on top of its main anti-stress action. Combined with temazepam, the nocturnal sedation can stack.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Passionflower and temazepam both calm the nervous system through overlapping pathways. Combining them can mean stronger nocturnal sedation and a heavier morning hangover.
Valerian and temazepam both promote sedation through overlapping pathways. Both are used for sleep; combining them can mean deeper-than-intended sedation and a heavier morning hangover.
Glucuronidation (no CYP interaction)
Temazepam is broken down by a different enzyme system (glucuronidation) than the one St John's Wort affects. We treat this pair as no expected interaction.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
For adults over 18.
This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, pharmacist, or specialist before making them, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologySomething missing?
If a supplement or medication you take isn't in our autocomplete, tell us and we'll add it in the next quarterly update.