NMN and medications.
NMN is classified as a targeted supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.
NMN is a precursor to NAD+, a coenzyme central to energy metabolism that declines with age, most steeply after 40. It is graded C but upgrading, since human RCTs since 2020 consistently show NMN raises blood NAD+ and point to emerging functional benefits. Yoshino 2021 found 250mg/day improved muscle insulin sensitivity in prediabetic women, Igarashi 2022 showed muscle effects in older men, and Pencina 2023 reported improvements in cholesterol, blood pressure, and body weight at 1,000mg/day; a 2026 meta-analysis found modest blood pressure reductions in people over 60. The honest position is that this is an informed personal choice, not an established recommendation, and 500mg appears a reasonable midpoint. The single most important point is a hard one: NMN is contraindicated with any cancer history, because NAD+ fuels cell proliferation, so a cancer history must always be confirmed clear before use. It is otherwise well tolerated, with mild stomach upset and a common five-days-on, two-days-off pattern.
Below are the 3 documented pairs we have explicitly assessed for NMN: 3 amber. The pairs cluster around 1 mechanism: Additive glucose lowering. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Additive glucose lowering
NMN may modestly improve how your body responds to insulin. If you take gliclazide, which lowers blood sugar, the two together could in theory push blood sugar lower than intended. This has not been studied directly. If you take both, monitor for signs of low blood sugar and speak to your diabetes team before starting.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
NMN may modestly improve how your body responds to insulin. If you inject insulin, the two together could in theory lower blood sugar more than your current dose is set for. This has not been studied directly. If you take both, monitor your blood sugar and speak to your diabetes team before starting.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
NMN may modestly improve how your body responds to insulin. If you inject insulin, the two together could in theory lower blood sugar more than your current dose is set for. This has not been studied directly. If you take both, monitor your blood sugar and speak to your diabetes team before starting.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyWant this checked across everything you take?
This page checks the pairs you enter. The personalised Distil report goes further:
- the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
- where your current routine may be leaving you short of your goals
- the evidence-backed compounds worth adding, and the ones worth dropping
It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.
See a real sample reportSomething missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.