Supplements and Insulin aspart.
Insulin aspart, sold under the brand names NovoRapid, Fiasp, Trurapi, is insulin replacement therapy for type 1 or insulin-requiring type 2 diabetes.
Insulin aspart is insulin replacement therapy. It is used universally in type 1 diabetes and in type 2 diabetes that has progressed to needing insulin. The supplement surface is small, because insulin is a peptide with no CYP metabolism and no plasma protein displacement story. The clinically important issue is anything that affects glucose handling. Berberine. Cinnamon (at habitual food amounts not clinically significant; at extract doses a small additive effect). Chromium at high doses. Alpha lipoic acid. And the GLP-1 mimetic supplement category. All carry small additive glycaemic effects that, stacked on top of an insulin regimen, can drive hypoglycaemia. Patients on insulin who add such a supplement benefit from more frequent glucose monitoring in the first two to four weeks of the change. Vitamin B12 status matters too, because most Type 2 patients carry metformin alongside their insulin.
Below are the 3 documented pairs we have explicitly assessed against Insulin aspart in the Distil database: 3 amber. The pairs cluster around 1 mechanism: Additive glucose lowering. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below is assessed against PubMed-indexed evidence.
Additive glucose lowering
Amber Does Alpha Lipoic Acid interact with ?
Alpha lipoic acid may improve how your body responds to insulin, which can lower blood sugar on top of the insulin you inject. This may increase the chance of glucose going too low. If you take alpha lipoic acid with insulin, monitor your blood glucose closely, especially early on, and your doctor may need to reduce your insulin dose.
Evidence: Supported by human study data.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does Holy Basil interact with ?
Holy basil (tulsi) may lower blood sugar on its own, on top of the insulin you inject. This may increase the chance of glucose going too low. If you take holy basil with insulin, monitor your blood glucose closely, especially early on, and your doctor may need to reduce your insulin dose.
Evidence: Limited human data, based on case reports and a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does NMN interact with ?
Taking NMN while you inject insulin could in theory lower blood sugar more than your current dose is set for, because NMN may modestly improve how your body responds to insulin. This has not been studied directly. If you take both, monitor your blood sugar and speak to your diabetes team before starting.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
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