Supplement · Grade B

Lycopene and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Lycopene is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

Lycopene is the red carotenoid pigment that gives tomatoes their colour, taken as an antioxidant with interest in prostate and heart health. The evidence is Grade B for prostate health and cardiovascular protection, where it appears to limit LDL oxidation, with additional interest in skin photoprotection. The honest framing is that this is largely observational and biomarker evidence rather than proof it prevents disease, so treat it as a sensible antioxidant input alongside a tomato-rich diet rather than a standalone shield. The usual dose is 15 to 30mg from tomato extract, and it is most relevant for men over 40 thinking about prostate health, or anyone targeting cardiovascular or skin support. No significant drug interactions are documented for it, which keeps it easy to add. The only notable side effect is a harmless orange skin tint at very high doses. A practical note: it absorbs better with a little dietary fat, much as cooked tomatoes deliver more than raw.

We have not yet completed an explicit assessment of medications for Lycopene in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Lycopene alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.