L-Glutamine and medications.
L-Glutamine is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.
L-glutamine is an amino acid that the gut lining and immune cells use heavily as fuel, which is why it is studied for mucosal repair and recovery. The evidence is Grade B for gut lining integrity and post-exercise recovery, and it is not for critical illness or intensive care: the largest trial in that setting found glutamine was associated with higher mortality, so this is a gut and recovery compound only. The honest framing is that this is a targeted compound, not a general daily supplement: the specific cases are gut lining issues such as IBD or IBS and high training loads, at 5 to 10g daily for gut health or 10 to 20g after heavy exercise. Several groups need caution or exclusion. People with liver disease should avoid it because glutamine breakdown produces ammonia. Kidney disease (CKD3+) warrants a lower dose under GP supervision, and active cancer needs oncologist review since some tumours use glutamine as fuel. It may also modestly lower the seizure threshold, so flag it if you take anticonvulsants. Outside those situations it is well tolerated.
We have not yet completed an explicit assessment of medications for L-Glutamine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take L-Glutamine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
No affiliates. No commission. We earn nothing on what you buy.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 introductory price for early customers. Standard price £79.
Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.