Choline and medications.
Choline is in the Distil supplement database, evidence Grade A. The page below lists every medication we have explicitly assessed it against.
Choline is an essential nutrient that most people in the UK fall short of: over 90% sit below the Adequate Intake. It does several jobs at once, clearing fat from the liver, donating methyl groups, building the neurotransmitter acetylcholine and supporting fetal brain development. The evidence is Grade A as an essential nutrient with an established intake target, and Grade B for liver benefit, where the shape of the evidence is deficiency: Niculescu 2007 showed organ stress, including liver fat, when healthy adults were fed a low-choline diet, and Yu 2014 linked higher intake to lower fatty liver risk in normal-weight adults in a large cohort. The cognitive use in adults sits at Grade C: no trial we hold tests choline itself for cognition outside pregnancy, and the memory trials often quoted for it used citicoline, a different compound with its own entry here. Typical dosing is 400 to 550mg a day, rising toward 1,000mg for liver health. Vegans are often low because eggs are the main dietary source. The key stacking link is positive: choline works with folate and B12 in the methylation cycle and acts as a backup methyl donor for people with MTHFR variants. Above 3,500mg a day it can cause a fishy body odour, so there is little reason to go that high.
We have not yet completed an explicit assessment of medications for Choline in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Choline alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 until 30 June 2027 · £79 from 1 July 2027.
Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. What people flag joins the queue of what we add next.