Butyrate and medications.
Butyrate is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.
Butyrate is a short-chain fatty acid that is the main fuel for the cells lining the colon, and supplements aim to support gut barrier integrity, ease IBS symptoms and help maintain remission in inflammatory bowel disease. Doses run 150 to 600mg a day as microencapsulated sodium or calcium butyrate, or 600 to 1,200mg of tributyrin. Form matters a great deal: plain sodium butyrate is absorbed high in the gut before it reaches the colon where it is needed, so a microencapsulated or tributyrin version that releases lower down is the sensible choice. The Grade B evidence supports gut barrier repair and reduced permeability, with trial data on diverticulitis and functional constipation, though it is not a cure for IBD. On interactions, it stacks well rather than clashing: prebiotics like inulin, FOS and psyllium generate more butyrate through fermentation, and probiotics complement it. Early bloating tends to settle. A practical gut-barrier option, best taken in the right delivery form.
We have not yet completed an explicit assessment of medications for Butyrate in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Butyrate alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.