Medication · aminosalicylate

Supplements and Sulfasalazine.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Sulfasalazine, sold under the brand names Salazopyrin EN-tabs, Salazopyrin, is an aminosalicylate: it acts topically on inflamed colonic mucosa in inflammatory bowel disease.

Sulfasalazine is an aminosalicylate (5-ASA), used in ulcerative colitis and some forms of Crohn disease. The class acts locally on inflamed colonic mucosa, with mesalazine as the dominant agent in current UK prescribing. Sulfasalazine remains in use for rheumatoid arthritis. Mechanism is local inhibition of prostaglandin and leukotriene synthesis at the colonic epithelium. The supplement surface is small because the drug acts locally with limited systemic absorption. Folate depletion can occur with sulfasalazine (the sulpha moiety competes with folate metabolism), and folate supplementation is sometimes given alongside. Iron deficiency is common in active inflammatory bowel disease and may need supplementation, with the standard separation rules for oral iron and oral 5-ASA. Probiotic use during active IBD is studied but the evidence base for specific strains remains modest. NSAIDs warrant care given the IBD relapse signal.

We have not yet completed an explicit assessment of supplement interactions with Sulfasalazine in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Sulfasalazine alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.