Does St John's Wort interact with Reboxetine?

Medication · antidepressant other

Supplements and Reboxetine.

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Reboxetine, sold under the brand name Edronax, is an antidepressant: depending on the agent, it acts on serotonin, noradrenaline, or both.

Reboxetine sits in the BNF "other antidepressants" group. The group includes the SNRIs (venlafaxine, duloxetine), the atypicals (mirtazapine, agomelatine, vortioxetine), and the older tetracyclics. The clinical class matters more than the BNF group, because the supplement profile differs sharply across it. SNRIs share the SSRI serotonergic concerns. Mirtazapine sits closer to the sedating, appetite-stimulating profile. Agomelatine is heavily liver-metabolised with mandatory LFT monitoring. Where these antidepressants share a supplement surface, it is St John's Wort (hard exclude across the class), 5-HTP (hard exclude on serotonergic grounds), rhodiola, and any supplement with significant sedating or activating effect depending on the agent. Discontinuation profiles differ too. Venlafaxine has the heaviest withdrawal syndrome of common antidepressants. Agomelatine probably the lightest.

Below are the 1 documented pair we have explicitly assessed against Reboxetine in the Distil database: 1 amber. The pairs cluster around 1 mechanism: CYP3A4 induction. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 15 June 2026. Each interaction below is assessed against PubMed-indexed evidence.

CYP3A4 induction

Amber Does St John's Wort interact with ?

St John's Wort can speed up the breakdown of reboxetine, which may leave it less effective than expected at the prescribed dose. Talk to whoever prescribed it before combining.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

PMID 13129991 · BNF: Hypericum · BNF: Reboxetine

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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