Supplements and Quetiapine.
Quetiapine, sold under the brand names Seroquel, Seroquel XL, Sondate XL, Atrolak XL, Mintreleq XL, is an antipsychotic: it antagonises dopamine D2 receptors and (for atypicals) serotonin receptors.
Quetiapine is an antipsychotic medicine. The class divides into typicals (haloperidol, chlorpromazine, older agents) and atypicals (olanzapine, quetiapine, risperidone, aripiprazole, the newer agents). Both block dopamine D2 receptors. The atypicals add 5-HT2 receptor blockade and a different side effect profile. Most UK community prescribing is atypicals. The supplement surface includes three patterns: additive sedation (especially with quetiapine), QT prolongation (haloperidol, ziprasidone, some others), and CYP interactions for the more 3A4-sensitive agents in the class. Metabolic side effects (weight gain, glucose dysregulation, lipid effects) underpin the routine monitoring that NICE NG178 recommends. St John's Wort is flagged by the BNF across the class given enzyme induction concerns. Specific supplements with the closest serotonergic overlap (5-HTP, SAMe at high dose, saffron extract) warrant care, particularly alongside atypicals with significant 5-HT2 activity.
Below are the 1 documented pair we have explicitly assessed against Quetiapine in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Reduced antipsychotic effect. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 15 June 2026. Each interaction below is assessed against PubMed-indexed evidence.
Reduced antipsychotic effect
Amber Does Vitex interact with ?
Vitex (chasteberry) gently nudges the brain's dopamine system, which can in theory work against antipsychotics. Quetiapine acts only loosely on dopamine, so any effect is likely small, but if you take it for a mental-health condition it is still worth mentioning vitex to your prescriber before adding it.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
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