Medication · penicillin

Supplements and Phenoxymethylpenicillin.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Phenoxymethylpenicillin is classified under "penicillin" in the BNF.

Phenoxymethylpenicillin is an antibiotic, usually taken as a short course, and the supplement questions people ask most when given one have reassuring answers. Probiotics are fine to take alongside it and lower the chance of antibiotic-related diarrhoea: space a bacterial probiotic, most Lactobacillus or Bifidobacterium products, about two hours from your dose, while Saccharomyces boulardii, which is a yeast, can be taken at the same time. Most everyday vitamins and minerals have no significant interaction with a short course of Phenoxymethylpenicillin, so a daily multivitamin, vitamin D or vitamin C is generally not a concern. The combinations that genuinely matter are listed below with their evidence, and they tend to be specific: supplements that thin the blood, serotonergic supplements stacked on certain antibiotics, and supplements that are really a prescription drug in disguise, such as red yeast rice, which contains the statin lovastatin. The sensible step in every case is to tell your pharmacist what you already take, which is free at any UK community pharmacy.

We have not yet completed an explicit assessment of supplement interactions with Phenoxymethylpenicillin in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Phenoxymethylpenicillin alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

Database last updated 2026-11-13. Free for everyone. No account, no paywall. · Browse coverage A-Z

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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Anything we should know? (optional)

Pick any that apply. We adjust the findings where context changes the answer.

I confirm I am 18 or over. This tool gives evidence-graded information, not medical advice; always discuss changes with your GP or pharmacist.

Add all the supplements and medications you take, then check them together in one go.

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How the checker decides

Every result has a source

Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.

Four kinds of answer

Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.

Severe
Caution
No known interaction
Not yet assessed

Nothing in our data is not a clearance

When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.

Read the full methodology

The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

£49 until 30 June 2027 · £79 from 1 July 2027.

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Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. What people flag joins the queue of what we add next.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.