Supplements and Naratriptan.
Naratriptan, sold under the brand name Naramig, is an analgesic.
Naratriptan (brand names Naramig) sits in the Distil medication database. The BNF classifies it under "analgesics". This means it sits outside the high-volume therapeutic classes (statins, PPIs, ACE inhibitors, SSRIs) where supplement-interaction surfaces are densely studied, and the published evidence base for specific supplement pairs is correspondingly thinner. Where interactions are documented in the Distil database, they are listed below with their clinical-reference citation; where pairs have not been explicitly assessed, the missing-item form at the bottom of the page routes them into our next curation pass. Anyone combining Naratriptan with a regular supplement stack benefits from explicit GP or pharmacist awareness rather than assuming no interaction exists by default.
Below are the 3 documented pairs we have explicitly assessed against Naratriptan in the Distil database: 1 red and 2 amber. The pairs cluster around 1 mechanism: Additive serotonergic activity. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 13 September 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive serotonergic activity
Red Does 5-HTP interact with ?
5-HTP is turned into serotonin in the body, and naratriptan is a migraine medicine that acts on serotonin receptors, so taking the two together can cause serotonin syndrome (agitation, sweating, tremor, a racing heart, confusion). Do not take 5-HTP with naratriptan; if you already take both, tell the prescriber who manages your naratriptan, and do not stop naratriptan on your own.
Evidence: Limited human data, from small studies or case reports, alongside a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does Rhodiola Rosea interact with ?
Rhodiola has mild effects on serotonin pathways, and naratriptan is a serotonin-receptor drug used for migraine, so in theory taking them together could add to that serotonin effect. The American Headache Society reviewed the published cases of serotonin syndrome with triptans and found the evidence too weak to show a link, while still advising vigilance, so it is worth mentioning the rhodiola to your GP, especially if you also take an antidepressant. If you notice restlessness, sweating, tremor, or a racing heart, stop and seek advice.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does St John's Wort interact with ?
St John's Wort raises serotonin in its own right, and naratriptan is a serotonin-receptor drug for migraine. In theory the two could add up. The American Headache Society reviewed the published cases of serotonin syndrome with triptans and found the evidence too weak to show a link, while still advising vigilance, and the UK prescribing information for naratriptan warns that side effects may be more common with St John's Wort. Be alert to agitation, sweating, tremor, shivering or a racing heart, and mention the St John's Wort to your GP, especially if you also take an antidepressant.
Evidence: Limited human data, from small studies or case reports, alongside a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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