Supplements and Methadone hydrochloride.
Methadone hydrochloride, sold under the brand names Methadose, Physeptone, is an opioid analgesic.
Methadone hydrochloride is an opioid analgesic. The class binds primarily to mu receptors, producing analgesia, sedation, respiratory depression at high doses, and a documented dependence profile. UK primary care prescribing has shifted substantially since the early 2010s away from chronic opioid use for non-cancer pain. The shift follows Faculty of Pain Medicine and NHS England stewardship guidance. The supplement surface includes three patterns. Additive CNS depression (alcohol, benzodiazepines, kava, valerian at higher doses, magnesium glycinate at high doses at bedtime). Constipation amplification (almost universal with chronic opioid use). And serotonergic concerns for the more serotonergic opioids when combined with SSRIs, SNRIs, MAOIs, 5-HTP, or rhodiola. Tramadol is the textbook example for the serotonergic concern, with pethidine to a lesser extent. The BNF and MHRA flag the combination.
We have not yet completed an explicit assessment of supplement interactions with Methadone hydrochloride in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Methadone hydrochloride alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
No affiliates. No commission. We earn nothing on what you buy.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 introductory price for early customers. Standard price £79.
Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.