Supplements and Estradiol with progestogen.
Estradiol with progestogen is hormone replacement therapy (oestrogen component) for menopausal symptoms.
Estradiol with progestogen is hormone replacement therapy (the oestrogen component). UK prescribing has shifted substantially since the early 2000s WHI trial retreat. Transdermal oestradiol is now the preferred delivery route over oral conjugated equine oestrogens, because the VTE and stroke risk signals were largely associated with the oral route. The supplement surface for the transdermal route is small, because the gut wall and first-pass liver metabolism are bypassed. Oral oestrogen formulations remain in CYP3A4 territory. St John's Wort is flagged by the BNF for potentially reduced efficacy. Symptom relief supplements often co-used during HRT (black cohosh, soya isoflavones, red clover, evening primrose oil) sit on top of HRT without strong interaction signals. The evidence base for any of them as additive benefit is modest. Vitamin D and calcium status matter for the bone density conversation.
Below are the 1 documented pair we have explicitly assessed against Estradiol with progestogen in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Hormonal axis modulation. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 17 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Hormonal axis modulation
Amber Does Vitex interact with ?
Vitex (chasteberry) acts on the body's hormone signals: it lowers prolactin and, in lab studies, gently nudges oestrogen and progesterone receptors. Combined HRT tops up both oestrogen and progesterone to ease menopausal symptoms, so in theory vitex could pull against that balance, and the HRT could equally blunt what vitex is meant to do. There is no study showing this actually happens, so it is a caution rather than a firm warning. If you take combined HRT, it is worth mentioning vitex to your prescriber before adding it.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
No affiliates. No commission. We earn nothing on what you buy.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 introductory price for early customers. Standard price £79.
Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.