Does Melatonin interact with Doxazosin mesilate?

Medication · other hypertension and heart failure

Supplements and Doxazosin mesilate.

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Doxazosin mesilate, sold under the brand names Cardura, Doxadura, Slocinx XL, is classified under "hypertension and heart failure" in the BNF.

Doxazosin mesilate (brand names Cardura, Doxadura, Slocinx XL) sits at NHSBSA prescribing rank 30 in the 2024/25 PCA statistics. The BNF classifies it under "hypertension and heart failure". This means it sits outside the high-volume therapeutic classes (statins, PPIs, ACE inhibitors, SSRIs) where supplement-interaction surfaces are densely studied, and the published evidence base for specific supplement pairs is correspondingly thinner. Where interactions are documented in the Distil database, they are listed below with their clinical-reference citation; where pairs have not been explicitly assessed, the missing-item form at the bottom of the page routes them into our next curation pass. Anyone combining Doxazosin mesilate with a regular supplement stack benefits from explicit GP or pharmacist awareness rather than assuming no interaction exists by default.

Below are the 1 documented pair we have explicitly assessed against Doxazosin mesilate in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Additive blood-pressure lowering. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.

Additive blood-pressure lowering

Amber Does Melatonin interact with ?

Taken at night, melatonin can modestly lower blood pressure during sleep. Combined with a blood-pressure medicine like doxazosin this may add up to a slightly larger drop than the medicine alone. Doxazosin can already cause dizziness on standing, so if you notice this, check your blood pressure and mention it to your prescriber.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

PMID 14732734 · BNF: Melatonin · BNF: Doxazosin

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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