Medication · retinoid

Supplements and Acitretin.

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Acitretin, sold under the brand names Neotigason, Soriatane, is classified under "retinoid" in the BNF.

Acitretin (brand names Neotigason, Soriatane) sits in the Distil medication database. The BNF classifies it under "retinoid". This means it sits outside the high-volume therapeutic classes (statins, PPIs, ACE inhibitors, SSRIs) where supplement-interaction surfaces are densely studied, and the published evidence base for specific supplement pairs is correspondingly thinner. Where interactions are documented in the Distil database, they are listed below with their clinical-reference citation; where pairs have not been explicitly assessed, the missing-item form at the bottom of the page routes them into our next curation pass. Anyone combining Acitretin with a regular supplement stack benefits from explicit GP or pharmacist awareness rather than assuming no interaction exists by default.

Below are the 1 documented pair we have explicitly assessed against Acitretin in the Distil database: 1 red. The pairs cluster around 1 mechanism: Additive vitamin A toxicity. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 8 June 2026. Each interaction below is assessed against PubMed-indexed evidence.

Additive vitamin A toxicity

Red Does Vitamin A interact with ?

Acitretin is a form of vitamin A, so adding a vitamin A supplement piles onto the same load and can tip you into vitamin A excess. This raises the risk of side effects such as dry and cracked skin and lips, hair thinning, raised blood fats, liver strain, and raised pressure in the skull. Do not take vitamin A supplements while on acitretin unless your prescriber tells you to.

Evidence: Well established across multiple human studies or interaction references.

PMID 1377120 · PMID 15470719 · PMID 20000864 · BNF: Acitretin

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

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the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-graded compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 founder pricing while we earn our first reviews. The interactions check is one section of it, and you can read a real one in full before you decide.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.