TMG and medications.
TMG is in the Distil supplement database, evidence Grade A. The page below lists every medication we have explicitly assessed it against.
TMG, also called trimethylglycine or betaine, is a methyl donor whose best-established use is lowering homocysteine, a marker tied to cardiovascular and dementia risk. The evidence for homocysteine reduction is Grade A, supported by Olthof's work, with a weaker Grade B case for strength and power output from resistance training, anchored by Cholewa. The usual dose is 1.25 to 2.5g daily. Its main relevance to other supplements is cooperative rather than cautionary: TMG works within the methylation cycle alongside methylcobalamin B12 and methylfolate, which makes it a sensible pairing for people with an MTHFR variant who are already taking methylfolate. There are no major drug interactions noted. At higher doses it can cause loose stools or stomach upset, and a small subset of people with an FMO3 variant notice a fishy body odour. It is a clean, well-studied option where the goal is methylation support or bringing homocysteine down.
We have not yet completed an explicit assessment of medications for TMG in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take TMG alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.