Supplement · Not recommended

Spermidine and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Spermidine is in the Distil database but is not recommended: it is graded for none of the goals we score, so a Distil report never adds it to a stack. The page below lists every medication we have explicitly assessed it against.

Spermidine is a naturally occurring polyamine, usually supplemented as wheat germ extract at 1 to 3mg a day. Its main mechanism is inducing autophagy, the cellular recycling process, which underpins interest in hair follicle cycling. The evidence is Grade B to C and mostly epidemiological. We do not recommend it for longevity or for cardiovascular health, and the reason is the gap between the two kinds of study behind it. People who eat more spermidine-rich food do live longer in cohort data, but the only randomised trial of the supplement, twelve months in a hundred older adults, found no effect on its main outcome or on any other measure it took, did not raise blood polyamine levels, and used a daily dose its own authors put at about a tenth of what people already get from food. Neither study we cite has a cardiovascular endpoint of any kind. The cognitive claim is not supported either: that same trial found no improvement in memory versus placebo, so spermidine should not be described as a cognitive compound despite how it is often marketed. There are no known drug interactions at supplemental doses, and tolerance is good below 5mg a day, with limited long-term safety data above that. Caution applies in active cancer because autophagy modulation cuts both ways in tumour biology, so flag for oncologist review first. Anyone with coeliac disease should confirm a gluten-free or synthetic source rather than wheat germ.

We have not yet completed an explicit assessment of medications for Spermidine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Spermidine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

Database last updated 2026-11-13. Free for everyone. No account, no paywall. · Browse coverage A-Z

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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How the checker decides

Every result has a source

Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.

Four kinds of answer

Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.

Severe
Caution
No known interaction
Not yet assessed

Nothing in our data is not a clearance

When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.

Read the full methodology

The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

what your diet already covers, so you are not adding a capsule for something food is already handling
which evidence-graded compounds are worth considering for your goals, and which were considered but left out
what to keep, change or stop from what you already take, plus the order to introduce anything new
how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.