Supplement · Grade B/C

Spermidine and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Spermidine is classified as a targeted supplement in the Distil database, evidence Grade B/C. The page below lists every medication we have explicitly assessed it against.

Spermidine is a naturally occurring polyamine, usually supplemented as wheat germ extract at 1 to 3mg a day. Its main mechanism is inducing autophagy, the cellular recycling process, which underpins interest in longevity, cardiovascular protection and hair follicle cycling. The evidence is Grade B to C and mostly epidemiological: higher dietary spermidine intake tracks with lower mortality in cohort studies. One honest caveat matters here. The cognitive claim is not supported by trial data. The only human RCT found no improvement in memory versus placebo, so spermidine should not be presented as a cognitive compound despite how it is often marketed. There are no known drug interactions at supplemental doses, and tolerance is good below 5mg a day, with limited long-term safety data above that. Caution applies in active cancer because autophagy modulation cuts both ways in tumour biology, so flag for oncologist review first. Anyone with coeliac disease should confirm a gluten-free or synthetic source rather than wheat germ.

We have not yet completed an explicit assessment of medications for Spermidine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Spermidine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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Anything we should know? (optional)

Pick any that apply. We adjust the findings where context changes the answer.

I confirm I am 18 or over. This tool gives evidence-graded information, not medical advice; always discuss changes with your GP or pharmacist.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

Want this checked across everything you take?

This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

See a real sample report

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.