Spermidine and medications.
Spermidine is classified as a targeted supplement in the Distil database, evidence Grade B/C. The page below lists every medication we have explicitly assessed it against.
Spermidine is a naturally occurring polyamine, usually supplemented as wheat germ extract at 1 to 3mg a day. Its main mechanism is inducing autophagy, the cellular recycling process, which underpins interest in longevity, cardiovascular protection and hair follicle cycling. The evidence is Grade B to C and mostly epidemiological: higher dietary spermidine intake tracks with lower mortality in cohort studies. One honest caveat matters here. The cognitive claim is not supported by trial data. The only human RCT found no improvement in memory versus placebo, so spermidine should not be presented as a cognitive compound despite how it is often marketed. There are no known drug interactions at supplemental doses, and tolerance is good below 5mg a day, with limited long-term safety data above that. Caution applies in active cancer because autophagy modulation cuts both ways in tumour biology, so flag for oncologist review first. Anyone with coeliac disease should confirm a gluten-free or synthetic source rather than wheat germ.
We have not yet completed an explicit assessment of medications for Spermidine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Spermidine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.