Supplement · Grade B

PQQ and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

PQQ is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

PQQ, or pyrroloquinoline quinone, is a small redox-active compound taken at 10 to 20mg a day. Its distinctive mechanism is mitochondrial biogenesis: it appears to stimulate the formation of new mitochondria through activation of PGC-1alpha, which sets it apart from CoQ10, which supports the mitochondria you already have, and from NMN or NR, which top up NAD+. The Grade B evidence comes from small human trials suggesting better attention, working memory and reduced fatigue, mostly in older adults, so the cognitive claims are promising rather than settled. It also acts as an antioxidant. On the interaction side there is little to worry about: no meaningful negative interactions are reported at standard doses, and it pairs sensibly with CoQ10 and with NMN or NR because the mechanisms complement each other. Tolerance in trials has been good. Treat it as a reasonable mitochondrial-support option rather than a proven cognitive enhancer, and keep the dose modest.

We have not yet completed an explicit assessment of medications for PQQ in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take PQQ alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

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This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.