Supplement · Grade B

Phosphatidylserine and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Phosphatidylserine is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

Phosphatidylserine is a phospholipid that sits in the membranes of brain cells, where it helps signalling between neurons. The evidence here is Grade B, and it carries an FDA qualified health claim for age-related cognitive decline. The best controlled work, like Kato-Kataoka 2010, found soy-derived phosphatidylserine improved memory, particularly delayed verbal recall, in older adults with mild memory complaints. It may also blunt the cortisol rise after hard exercise. Be honest about the limits: a 2026 trial in children with ADHD found it did not improve core attention or hyperactivity, though it did reduce some difficult behaviours, so it is adjunctive support, not a stimulant substitute. On interactions, it pairs well with omega-3 for membrane integrity, and it carries only a negligible blood-thinning effect, safe at 300 to 400mg even alongside other antiplatelet compounds. Take it in the morning or midday; later doses can disturb sleep.

We have not yet completed an explicit assessment of medications for Phosphatidylserine in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Phosphatidylserine alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.