Supplement · Grade B

Palmitoylethanolamide (PEA) and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Palmitoylethanolamide (PEA) is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

Palmitoylethanolamide, or PEA, is a fatty-acid molecule the body makes itself, taken to ease chronic pain. It works on the PPAR-alpha receptor and the wider endocannabinoid system, calming the inflammatory and nerve signals that keep pain going, which is why it tends to suit neuropathic and nociplastic pain such as sciatica, neuropathy and fibromyalgia-type pain. The evidence is Grade B, with two recent meta-analyses showing it reduces pain scores, and the effect tends to grow with continued use rather than appearing overnight. The practical points matter here. Use a micronised or ultramicronised form, since standard PEA is poorly absorbed, at 600 to 1,200mg a day, and give it at least eight weeks before judging whether it helps. It is very well tolerated, with no significant drug interactions documented, but it is support alongside a proper diagnosis of the pain, not a replacement for one.

We have not yet completed an explicit assessment of medications for Palmitoylethanolamide (PEA) in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Palmitoylethanolamide (PEA) alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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the evidence-graded compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 founder pricing while we earn our first reviews. The interactions check is one section of it, and you can read a real one in full before you decide.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.