Supplement · Grade A

Myo-Inositol and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Myo-Inositol is in the Distil supplement database, evidence Grade A. The page below lists every medication we have explicitly assessed it against.

Myo-inositol is a sugar alcohol your cells use as a messenger in insulin and hormone signalling, which is why it has become a mainstay for polycystic ovary syndrome. This is one of the few supplements here at Grade A, specifically for PCOS, with Grade B evidence for anxiety and insulin sensitivity on top. For PCOS the studied approach is 1,800 to 4,000mg myo-inositol combined with d-chiro-inositol in a 40:1 ratio, which works better than myo-inositol alone; general use sits around 2 to 4g daily. Benefits extend to insulin sensitivity, female fertility and egg quality, and some trials put its anxiety effect in the range of low-dose SSRIs, though that comparison should be read cautiously. On interactions it is clean: no significant drug interactions are documented. The main side effect is stomach upset, easily managed by splitting the dose. A practical note: give it three months of consistent use, since hormonal and metabolic changes are gradual.

We have not yet completed an explicit assessment of medications for Myo-Inositol in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Myo-Inositol alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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Your supplements

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

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If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.