Supplement · Grade B

Glutathione and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Glutathione is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.

Glutathione is the body's main internal antioxidant, and supplementing it sensibly comes down to form. Standard reduced glutathione absorbs poorly by mouth, so older products were largely ineffective; the S-acetyl and liposomal forms, taken at 250 to 1,000mg a day, are the ones with usable bioavailability (Richie 2015). The evidence is Grade B for liver support, antioxidant effects and skin, with Weschawalit 2017 suggesting improved skin tone and Honda 2017 showing reduced liver enzymes in NAFLD, though that latter trial was small and open-label. The honest limit is that most of the human data is early-stage. On interactions, glutathione is complementary rather than conflicting: NAC is a precursor that works through a different route, and the two can sit in the same stack, while vitamin C supports the same antioxidant network. The combination of NAC plus glycine, known as GlyNAC, has the strongest evidence for restoring glutathione. It is very safe, with mild stomach effects and a sulphur odour at high doses.

We have not yet completed an explicit assessment of medications for Glutathione in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Glutathione alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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Anything we should know? (optional)

Pick any that apply. We adjust the findings where context changes the answer.

I confirm I am 18 or over. This tool gives evidence-graded information, not medical advice; always discuss changes with your GP or pharmacist.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

Want this checked across everything you take?

This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

See a real sample report

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.