Eleuthero and medications.
Eleuthero is classified as a targeted supplement in the Distil database, evidence Grade B/C. The page below lists every medication we have explicitly assessed it against.
Eleuthero, sometimes called Siberian ginseng, is an adaptogen taken for fatigue, endurance, immune function and stress resilience. The evidence is Grade B to C and honestly mixed: the main chronic fatigue trial did not show overall benefit, though a moderate-fatigue subgroup may have improved at two months. Treat it as emerging rather than proven, with burnout and adrenal recovery as the most reasonable use and athletic endurance as a secondary one. The dose is 300 to 1,200mg a day of standardised extract, taken in the morning because it can disturb sleep later on. A few interactions deserve attention. There are case reports of eleuthero raising digoxin levels, so it should be flagged for anyone on that drug. It has mild reported platelet effects worth a GP note alongside anticoagulants, and it stacks additively with caffeine and other stimulants. It may modestly raise blood pressure, so flag it if hypertension is not controlled, and use caution with hormone-sensitive conditions given mild oestrogenic activity.
Below are the 3 documented pairs we have explicitly assessed for Eleuthero: 3 amber. The pairs cluster around 2 mechanisms: Digoxin assay interference and Immune-stimulant vs immunosuppressant (precautionary). Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Digoxin assay interference
Amber Does interact with Digoxin?
Siberian ginseng can make a digoxin blood test read higher (or lower) than your true level, depending on which test the lab uses. There is one older case where digoxin readings rose while taking it and fell each time it was stopped. Because digoxin has a narrow safe range, tell your GP or cardiology team if you take Siberian ginseng, and mention it before any digoxin level is checked.
Evidence: Limited human data, based on case reports and a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Immune-stimulant vs immunosuppressant (precautionary)
Amber Does interact with Ciclosporin?
Eleuthero (Siberian ginseng) is taken to stimulate the immune system, which in theory works against a medicine like ciclosporin that is meant to calm it. This has not been tested in people taking immune-suppressing medicines, so it is a cautious flag rather than a strong warning. If you take ciclosporin after a transplant or for an autoimmune condition, check with your specialist before starting eleuthero.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Tacrolimus?
Eleuthero (Siberian ginseng) is taken to stimulate the immune system, which in theory works against a medicine like tacrolimus that is meant to suppress it. This has not been tested in people taking immune-suppressing medicines, so it is a cautious flag rather than a strong warning. If you take tacrolimus after a transplant or for an autoimmune condition, check with your specialist before starting eleuthero.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
No affiliates. No commission. We earn nothing on what you buy.
How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 introductory price for early customers. Standard price £79.
Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.