Chromium Picolinate and medications.
Chromium Picolinate is in the Distil supplement database, evidence Grade B. The page below lists every medication we have explicitly assessed it against.
Chromium picolinate is a well-absorbed form of the trace mineral chromium, taken to support how the body handles glucose. It appears to improve insulin sensitivity and may reduce carbohydrate cravings, which is the basis of its Grade B rating for insulin sensitivity; the evidence for weight and mood is weaker, at Grade C. Typical doses are 200 to 400mcg. The interaction that matters is stacking glucose-lowering agents: combining chromium with metformin, berberine and alpha-lipoic acid together calls for monitoring, since the additive effect can push blood sugar too low. Antacids reduce its absorption, so separate them in time. At supplemental doses it is generally well tolerated, with occasional headache or GI upset; doses above 1,000mcg daily may stress the kidneys in people with kidney disease. Note that the picolinate form is safe and unrelated to the toxic industrial hexavalent chromium. If you are already on diabetes medication, treat any glucose-lowering stack as something to monitor with your GP.
Below are the 4 documented pairs we have explicitly assessed for Chromium Picolinate: 4 amber. The pairs cluster around 2 mechanisms: Absorption interference and Additive glucose lowering. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Absorption interference
Amber Does interact with Levothyroxine?
Chromium picolinate can bind levothyroxine in the gut and reduce how much of your thyroid hormone you absorb if you take them at the same time. This may make your thyroid treatment work less well. Take levothyroxine first thing on an empty stomach and take any chromium supplement several hours later, for example at lunchtime or bedtime.
Evidence: Supported by human study data.
Additive glucose lowering
Amber Does interact with Gliclazide?
Chromium may lower blood sugar by improving how your body responds to insulin. Gliclazide already lowers blood sugar, so taking the two together may add up and could push your glucose too low. If you take both, monitor your blood glucose, especially in the first few weeks, and your doctor may need to reduce the gliclazide dose.
Evidence: Limited human data, based on case reports and a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Insulin glargine?
Chromium may improve how your body responds to insulin, which can lower blood sugar on top of the insulin you inject. This may increase the chance of glucose going too low. If you take chromium with insulin, monitor your blood glucose closely, especially early on, and your doctor may need to reduce your insulin dose.
Evidence: Limited human data, based on case reports and a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Amber Does interact with Metformin?
Chromium may improve how your body responds to insulin and lower blood sugar. Metformin also lowers blood sugar, so the two may add up. The combination is generally manageable, but monitor your blood glucose, especially when you start chromium or change the dose, and your doctor may adjust the metformin if needed.
Evidence: Limited human data, based on case reports and a known mechanism.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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