Supplement · Grade C

Bifidobacterium longum 1714 and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Bifidobacterium longum 1714 is classified as a optimise supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.

Bifidobacterium longum 1714 is a specific probiotic strain, sold commercially as Zenflore by PrecisionBiotics, studied for the gut-brain axis rather than digestion. In a small crossover trial in healthy volunteers, a daily dose of one billion CFU tended to lower cortisol output and subjective anxiety under acute stress, reduced daily reported stress, and produced subtle visuospatial memory changes. The evidence is Grade C and honest about its limits: one pilot study of 22 people and one IBS trial where 1714 was combined with another strain, so its individual contribution cannot be separated. It may support stress resilience as an adjunct, not as a primary anxiety treatment. The strain number matters: effects do not generalise to other B. longum strains, so the label must say 1714. On interactions, separate it from antibiotics by at least two hours, since they kill live bacteria, and prebiotic fibre like inulin or FOS may help sustain it. Anyone immunocompromised should check with their clinician first.

We have not yet completed an explicit assessment of medications for Bifidobacterium longum 1714 in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Bifidobacterium longum 1714 alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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Your supplements

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

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If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.