Bifidobacterium longum 1714 and medications.
Bifidobacterium longum 1714 is in the Distil database but is not recommended: it is graded for none of the goals we score, so a Distil report never adds it to a stack. The page below lists every medication we have explicitly assessed it against.
Bifidobacterium longum 1714 is a specific probiotic strain, sold commercially as Zenflore by PrecisionBiotics, studied for the gut-brain axis. We do not currently recommend it for any goal, and the reason is the shape of the evidence. The first study gave 22 healthy men a placebo for four weeks and then the strain for four weeks, always in that order, and found lower cortisol and anxiety under a stress test and lower daily stress; with a fixed order, that change cannot be separated from time and expectation. Three randomised placebo-controlled trials followed. Two missed their main measure, overall sleep quality in poor sleepers and depression scores in adults with low mood. The third changed brain activity, its main measure, but found no difference in how stressed people felt under a social stress test. The sleep and depression trials found energy or vitality better on a secondary measure, which is worth watching but not enough to recommend it on. We do not recommend it for digestion either: the IBS study gave everyone the product with no placebo group, combined it with another strain, and reported bowel symptoms against the participants' own starting point. The strain number matters: effects do not generalise to other B. longum strains, so the label must say 1714. On interactions, separate it from antibiotics by at least two hours, since they kill live bacteria, and prebiotic fibre like inulin or FOS may help sustain it. Anyone immunocompromised, or with a heart valve problem or a central line, should check with their clinician first.
Below are the 16 documented pairs we have explicitly assessed for Bifidobacterium longum 1714: 6 caution and 10 good to know. The pairs cluster around 2 mechanisms: Immunosuppression caution and Probiotic timing with antibiotics. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Last reviewed 15 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Immunosuppression caution
Caution Does Bifidobacterium longum 1714 interact with Azathioprine?
If you take azathioprine, it is sensible to check with your specialist before starting this strain: azathioprine dampens the immune system, often for an autoimmune condition or after a transplant, and in people whose defences are significantly weakened there have been rare cases of a probiotic organism getting into the bloodstream and causing an infection. If you are seriously unwell in hospital or have a central line (a long-term drip line into a large vein, such as a PICC), start any probiotic, this strain included, only if the team caring for you agrees. Bifidobacterium longum 1714 is a live bacterium, and the evidence that probiotics are safe for most people comes from studies of people who were not significantly immunosuppressed, so on azathioprine let your specialist's advice decide.
Evidence: Supported by human study data.
Caution Does Bifidobacterium longum 1714 interact with Ciclosporin?
If you take ciclosporin, check with your specialist team before starting this strain: ciclosporin strongly dampens the immune system, usually after a transplant or for a serious autoimmune condition, and in people whose defences are this weakened there have been rare cases of a probiotic organism getting into the bloodstream and causing an infection. If you are seriously unwell in hospital or have a central line (a long-term drip line into a large vein, such as a PICC), start any probiotic, this strain included, only if the team caring for you agrees. Bifidobacterium longum 1714 is a live bacterium, and the evidence that probiotics are safe for most people comes from studies of people who were not significantly immunosuppressed, so on ciclosporin let your specialist team's advice decide.
Evidence: Supported by human study data.
Caution Does Bifidobacterium longum 1714 interact with Everolimus?
If you take everolimus, check with your specialist team before starting this strain: everolimus strongly dampens the immune system, used after a transplant or in some cancers, and in people whose defences are this weakened there have been rare cases of a probiotic organism getting into the bloodstream and causing an infection. If you are seriously unwell in hospital or have a central line (a long-term drip line into a large vein, such as a PICC), start any probiotic, this strain included, only if the team caring for you agrees. Bifidobacterium longum 1714 is a live bacterium, and the evidence that probiotics are safe for most people comes from studies of people who were not significantly immunosuppressed, so on everolimus let your specialist team's advice decide.
Evidence: Supported by human study data.
Caution Does Bifidobacterium longum 1714 interact with Methotrexate?
If you take methotrexate, it is sensible to check with your specialist before starting this strain: methotrexate dampens the immune system, and in people whose defences are significantly weakened there have been rare cases of a probiotic organism getting into the bloodstream and causing an infection. At the usual low weekly doses for arthritis or psoriasis this risk is small. If you are seriously unwell in hospital or have a central line (a long-term drip line into a large vein, such as a PICC), start any probiotic, this strain included, only if the team caring for you agrees. Bifidobacterium longum 1714 is a live bacterium, and the evidence that probiotics are safe for most people comes from studies of people who were not significantly immunosuppressed, so on methotrexate let your specialist's advice decide.
Evidence: Supported by human study data.
Caution Does Bifidobacterium longum 1714 interact with Sirolimus?
If you take sirolimus, check with your specialist team before starting this strain: sirolimus strongly dampens the immune system, usually after a transplant, and in people whose defences are this weakened there have been rare cases of a probiotic organism getting into the bloodstream and causing an infection. If you are seriously unwell in hospital or have a central line (a long-term drip line into a large vein, such as a PICC), start any probiotic, this strain included, only if the team caring for you agrees. Bifidobacterium longum 1714 is a live bacterium, and the evidence that probiotics are safe for most people comes from studies of people who were not significantly immunosuppressed, so on sirolimus let your specialist team's advice decide.
Evidence: Supported by human study data.
Caution Does Bifidobacterium longum 1714 interact with Tacrolimus?
If you take tacrolimus, check with your specialist team before starting this strain: tacrolimus strongly dampens the immune system, usually after a transplant or for a serious autoimmune condition, and in people whose defences are this weakened there have been rare cases of a probiotic organism getting into the bloodstream and causing an infection. If you are seriously unwell in hospital or have a central line (a long-term drip line into a large vein, such as a PICC), start any probiotic, this strain included, only if the team caring for you agrees. Bifidobacterium longum 1714 is a live bacterium, and the evidence that probiotics are safe for most people comes from studies of people who were not significantly immunosuppressed, so on tacrolimus let your specialist team's advice decide.
Evidence: Supported by human study data.
Probiotic timing with antibiotics
Good to know Does Bifidobacterium longum 1714 interact with Amoxicillin?
Bifidobacterium longum 1714 and amoxicillin are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your amoxicillin dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Ciprofloxacin?
Bifidobacterium longum 1714 and ciprofloxacin are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your ciprofloxacin dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Clarithromycin?
Bifidobacterium longum 1714 and clarithromycin are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your clarithromycin dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Co-trimoxazole?
Bifidobacterium longum 1714 and co-trimoxazole are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your co-trimoxazole dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Doxycycline?
Bifidobacterium longum 1714 and doxycycline are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your doxycycline dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Erythromycin?
Bifidobacterium longum 1714 and erythromycin are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your erythromycin dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Metronidazole?
Bifidobacterium longum 1714 and metronidazole are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your metronidazole dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Minocycline?
Bifidobacterium longum 1714 and minocycline are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your minocycline dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Nitrofurantoin?
Bifidobacterium longum 1714 and nitrofurantoin are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your nitrofurantoin dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
Good to know Does Bifidobacterium longum 1714 interact with Trimethoprim?
Bifidobacterium longum 1714 and trimethoprim are fine to use together. Bifidobacterium longum 1714 is a live bacterium, so space it about two hours away from your trimethoprim dose so the antibiotic does not reduce the live bacteria. The main exception is if your immune system is seriously weakened or you are critically ill in hospital, when any probiotic should be checked with your doctor first.
Evidence: Supported by human study data.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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