Apigenin and medications.
Apigenin is classified as a targeted supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.
Apigenin is a flavonoid found in chamomile, taken before bed for sleep quality and mild anxiety. It works by binding the benzodiazepine site on GABA-A receptors, which tends to reduce how long it takes to fall asleep and improve subjective sleep depth. The evidence is Grade C: chamomile extract trials are small but consistently show modest sleep quality gains. A common longevity claim, that apigenin preserves NAD+ by inhibiting CD38, rests on a citation that cannot stand, so it should not go into longevity stacks on that basis. The typical dose is 50mg of chamomile extract standardised to apigenin, 30 to 60 minutes before bed, and it pairs well with glycine and magnesium glycinate for a layered sleep approach. Because it acts on the same receptor site as benzodiazepines, it adds to their effect and to other sedatives, so flag those combinations to a GP. There is limited evidence of serotonergic overlap with SSRIs, worth a note rather than an exclusion. It causes drowsiness by design, so avoid driving afterwards.
We have not yet completed an explicit assessment of medications for Apigenin in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Apigenin alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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Something missing?
If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.