Supplement · Grade C

Apigenin and medications.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Apigenin is classified as a targeted supplement in the Distil database, evidence Grade C. The page below lists every medication we have explicitly assessed it against.

Apigenin is a flavonoid found in chamomile, taken before bed for sleep quality and mild anxiety. It works by binding the benzodiazepine site on GABA-A receptors, which tends to reduce how long it takes to fall asleep and improve subjective sleep depth. The evidence is Grade C: chamomile extract trials are small but consistently show modest sleep quality gains. A common longevity claim, that apigenin preserves NAD+ by inhibiting CD38, rests on a citation that cannot stand, so it should not go into longevity stacks on that basis. The typical dose is 50mg of chamomile extract standardised to apigenin, 30 to 60 minutes before bed, and it pairs well with glycine and magnesium glycinate for a layered sleep approach. Because it acts on the same receptor site as benzodiazepines, it adds to their effect and to other sedatives, so flag those combinations to a GP. There is limited evidence of serotonergic overlap with SSRIs, worth a note rather than an exclusion. It causes drowsiness by design, so avoid driving afterwards.

We have not yet completed an explicit assessment of medications for Apigenin in the Distil interactions database. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Apigenin alongside a medication, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

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the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.