Akkermansia muciniphila (pasteurised) and medications.
Akkermansia muciniphila (pasteurised) is in the Distil database but is not recommended: it is graded for none of the goals we score, so a Distil report never adds it to a stack. The page below lists every medication we have explicitly assessed it against.
Akkermansia muciniphila is a gut bacterium that lives in the protective mucus layer of the intestine, taken to support metabolic health. In Great Britain pasteurised Akkermansia is not yet authorised as a novel food, so it should not be on sale here as a supplement, although you may still see it sold; the duty to follow that rule sits with the seller, not with you, and the application to authorise it is still in progress, so this may change. Lower levels of it tend to track with obesity and type 2 diabetes, and supplementing it may improve insulin sensitivity. The evidence is Grade B and genuinely emerging, and it is narrower than it is often presented. The proof-of-concept trial was an exploratory pilot in which 32 people completed, and insulin sensitivity improved clearly against placebo. Its effects on body weight and fat mass did not reach significance, and a 2025 trial in type 2 diabetes found no significant difference between the treated and placebo groups on body weight overall, with weight and blood-sugar gains showing up only in the participants who happened to start with low gut levels of the bacterium. Since we have no way to measure your baseline level, we do not recommend it for weight or fat loss. The first trial gave 10 billion cells a day and found the pasteurised form did better than the live bacterium; the 2025 trial used a live strain. It is well tolerated, with mild digestive upset the main complaint. The interaction to know is immunosuppressant medication: if you take tacrolimus, ciclosporin, sirolimus, everolimus or azathioprine, or you are otherwise immunocompromised, check with your specialist before starting any bacterial product. The pasteurised form lowers the usual concern, but the immune data are incomplete.
Below are the 6 documented pairs we have explicitly assessed for Akkermansia muciniphila (pasteurised): 5 caution and 1 good to know. The pairs cluster around 2 mechanisms: Immunosuppression caution and Gut microbiome synergy. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not listed here is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by medication, and the missing-item form at the bottom of the page routes any uncatalogued medication into our next curation pass.
Documented interactions
Last reviewed 1 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Immunosuppression caution
Caution Does Akkermansia muciniphila (pasteurised) interact with Azathioprine?
If you take a medicine that suppresses your immune system, check with your specialist before starting any probiotic. The pasteurised (non-living) form used here lowers the usual concern, but immune data are incomplete, so a quick word with your team is the safe route.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Akkermansia muciniphila (pasteurised) interact with Ciclosporin?
If you take a medicine that suppresses your immune system, check with your specialist before starting any probiotic. The pasteurised (non-living) form used here lowers the usual concern, but immune data are incomplete, so a quick word with your team is the safe route.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Akkermansia muciniphila (pasteurised) interact with Everolimus?
If you take a medicine that suppresses your immune system, check with your specialist before starting any probiotic. The pasteurised (non-living) form used here lowers the usual concern, but immune data are incomplete, so a quick word with your team is the safe route.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Akkermansia muciniphila (pasteurised) interact with Sirolimus?
If you take a medicine that suppresses your immune system, check with your specialist before starting any probiotic. The pasteurised (non-living) form used here lowers the usual concern, but immune data are incomplete, so a quick word with your team is the safe route.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Akkermansia muciniphila (pasteurised) interact with Tacrolimus?
If you take a medicine that suppresses your immune system, check with your specialist before starting any probiotic. The pasteurised (non-living) form used here lowers the usual concern, but immune data are incomplete, so a quick word with your team is the safe route.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Gut microbiome synergy
Good to know Does Akkermansia muciniphila (pasteurised) interact with Metformin?
Akkermansia and metformin work in the same direction. Metformin itself tends to increase Akkermansia in the gut, so taking the supplement alongside it is complementary rather than a problem. No special timing is needed.
Evidence: Limited human data, from small studies or case reports.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope. Use the checker below to surface any medication, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
£49 until 30 June 2027 · £79 from 1 July 2027.
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