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Supplements and SSRIs.

What to avoid, what to use with caution, and what is safe alongside sertraline, citalopram, fluoxetine and other SSRIs.

SSRIs (selective serotonin reuptake inhibitors) raise serotonin levels in the synapse. Some supplements do the same, by a different mechanism. Combining them risks serotonin syndrome, a documented clinical emergency.

The hard exclusion is 5-HTP: never alongside an SSRI or any other antidepressant. St John’s Wort is also off the table, both for the serotonergic stack-up and because it induces CYP3A4 and accelerates clearance of many co-prescribed drugs. Saffron, ashwagandha, and SAM-e all sit in the cautious tier and need GP review before starting.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
Type the supplement name. Click each match to add it.
Brand or generic name works. Click each match to add it.

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If a supplement or medication you take isn't in our autocomplete, tell us and we'll add it in the next quarterly update.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history.