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Class landing · PPIs

Supplements and PPIs.

Omeprazole, lansoprazole and the absorption changes that affect supplement choice.

Proton pump inhibitors raise gastric pH. The downstream effect on supplements is twofold. Some supplements are not interacted with directly but their absorption pattern changes (non-haem iron, vitamin B12, magnesium). Long-term PPI use itself depletes these nutrients, which is why chronic PPI users sometimes need to supplement them at higher doses than the general population.

The strongest recommendations: monitor B12 after a year of daily PPI use, particularly in over-50s; consider magnesium repletion if blood levels run low; use iron bisglycinate rather than ferrous sulphate if iron is needed (less pH-dependent). None of these are emergency interactions; all are worth knowing if you take a daily PPI.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP or pharmacist, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
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How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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The full report

A full supplement review, built around you, not a generic stack.

The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.

  • what your diet already covers, so you are not adding a capsule for something food is already handling
  • which evidence-graded compounds are worth considering for your goals, and which were considered but left out
  • what to keep, change or stop from what you already take, plus the order to introduce anything new
  • how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment

The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.