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Supplements and PPIs.

Omeprazole, lansoprazole and the absorption changes that affect supplement choice.

Proton pump inhibitors raise gastric pH. The downstream effect on supplements is twofold. Some supplements are not interacted with directly but their absorption pattern changes (non-haem iron, vitamin B12, magnesium). Long-term PPI use itself depletes these nutrients, which is why chronic PPI users sometimes need to supplement them at higher doses than the general population.

The strongest recommendations: monitor B12 after a year of daily PPI use, particularly in over-50s; consider magnesium repletion if blood levels run low; use iron bisglycinate rather than ferrous sulphate if iron is needed (less pH-dependent). None of these are emergency interactions; all are worth knowing if you take a daily PPI.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
Type the supplement name. Click each match to add it.
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Pick any that apply. We adjust the findings where context changes the answer.
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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology
Your whole stack

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  • the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
  • where your current routine may be leaving you short of your goals
  • the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.