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Class landing · PPIs

Supplements and PPIs.

Omeprazole, lansoprazole and the absorption changes that affect supplement choice.

Proton pump inhibitors raise gastric pH. The downstream effect on supplements is twofold. Some supplements are not interacted with directly but their absorption pattern changes (non-haem iron, vitamin B12, magnesium). Long-term PPI use itself depletes these nutrients, which is why chronic PPI users sometimes need to supplement them at higher doses than the general population.

The strongest recommendations: monitor B12 after a year of daily PPI use, particularly in over-50s; consider magnesium repletion if blood levels run low; use iron bisglycinate rather than ferrous sulphate if iron is needed (less pH-dependent). None of these are emergency interactions; all are worth knowing if you take a daily PPI.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.
Type the supplement name. Click each match to add it.
Brand or generic name works. Click each match to add it.

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If a supplement or medication you take isn't in our autocomplete, tell us and we'll add it in the next quarterly update.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history.