Supplements and Tolterodine.
Tolterodine, sold under the brand names Detrusitol XL, Detrol, is an antimuscarinic agent for urinary urgency or overactive bladder.
Tolterodine is an antimuscarinic agent for urinary urgency or overactive bladder. The class blocks muscarinic acetylcholine receptors in the detrusor muscle, reducing involuntary contraction. UK prescribing includes solifenacin, tolterodine, oxybutynin, and mirabegron (technically a beta-3 agonist but in the same prescribing space). The supplement surface includes additive anticholinergic burden, which matters most in older patients given the cognitive decline signal that has emerged in long anticholinergic exposure data. Supplements with anticholinergic potential at high doses (some choline pathway compounds in reverse, certain antiemetic herbals) warrant care. Dry mouth. Constipation. Urinary retention. All three scale with dose. The NICE NG123 guideline pushes for review of indication and dose every six to twelve months, given the cognitive burden picture.
Below are the 1 documented pair we have explicitly assessed against Tolterodine in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Cholinergic vs anticholinergic (opposing). Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 15 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Cholinergic vs anticholinergic (opposing)
Amber Does Huperzine A interact with ?
Huperzine A raises acetylcholine while tolterodine blocks it, so each can work against the other. Huperzine A may make tolterodine less effective for bladder symptoms, and tolterodine may blunt any benefit from huperzine A. It is not dangerous, but the two are pulling in opposite directions, so it is worth a word with your prescriber.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
Read the full methodologyA full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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