Medication · antiparkinsonian

Supplements and Ropinirole hydrochloride.

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Ropinirole hydrochloride, sold under the brand names Requip, Requip XL, Adartrel, is used in Parkinson disease to modulate dopaminergic signalling.

Ropinirole hydrochloride is used in Parkinson disease to modulate dopaminergic signalling. The class includes levodopa (combined with carbidopa or benserazide to prevent peripheral conversion), dopamine agonists (ropinirole, pramipexole, rotigotine), MAO-B inhibitors (covered separately), COMT inhibitors, and amantadine. UK prescribing is overseen by neurology specialists. The supplement surface includes two specific timing rules. First, the protein and levodopa absorption rule. Large protein loads compete with levodopa for the same gut amino acid transporter, and need a 30 to 45 minute separation. Second, the iron and levodopa chelation rule. Iron supplements bind levodopa in the gut, reducing absorption and requiring strict separation. Vitamin B6 at high doses historically opposed levodopa monotherapy, but with carbidopa or benserazide given alongside this is no longer an issue at standard supplement doses. 5-HTP and St John's Wort warrant care, given serotonergic and MAO concerns.

Below are the 1 documented pair we have explicitly assessed against Ropinirole hydrochloride in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Dopaminergic potentiation (levodopa-sparing). Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Dopaminergic potentiation (levodopa-sparing)

Amber Vitex

Ropinirole works by boosting dopamine activity, and vitex (chasteberry) gently acts in the same direction, so the two could add together. If you take ropinirole for Parkinson's or restless legs, it is worth discussing vitex with your Parkinson's team rather than adding it yourself.

PMID 7890021 · PMID 39519010 · PMID 38075075 · BNF: Ropinirole

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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