Supplements and Rasagiline.
Rasagiline, sold under the brand name Azilect, is a selective MAO-B inhibitor used in Parkinson disease.
Rasagiline is a selective MAO-B inhibitor. It is used in Parkinson disease for symptomatic management and a possible effect on disease progression (selegiline, rasagiline, safinamide). MAO-B selectivity means less of the dietary tyramine concern that defines the older MAOIs. But selectivity scales inversely with dose. At higher doses the agents lose some of their B selectivity, and the MAOI class precautions begin to apply. The supplement surface that matters is serotonergic. 5-HTP combined with selegiline or rasagiline carries serotonin syndrome concern in case reports, and is the closest match for an inferred exclusion. St John's Wort and rhodiola are similarly flagged. Sympathomimetic supplements (yohimbe, bitter orange, panax ginseng, caffeine at high doses) carry care given the underlying mechanism. Other Parkinson medicines (levodopa, dopamine agonists) often run alongside an MAO-B inhibitor. Supplement decisions are best routed through the neurology team rather than community pharmacy.
Below are the 8 documented pairs we have explicitly assessed against Rasagiline in the Distil database: 6 red and 2 amber. The pairs cluster around 3 mechanisms: Additive serotonergic activity, MAOI pressor (blood-pressure surge), and Additive sympathomimetic activity. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below is assessed against PubMed-indexed evidence.
Additive serotonergic activity
Red Does 5-HTP interact with ?
Taking 5-HTP with rasagiline (an MAO-B inhibitor used for Parkinson's) can push serotonin to dangerous levels, because there is less MAO available to break it down, so we treat this as a do-not-combine pair. The combination has caused serotonin syndrome in case reports with other MAO inhibitors.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Red Does L-Tryptophan interact with ?
Taking L-tryptophan with rasagiline (an MAO-B inhibitor used for Parkinson's) can push serotonin to dangerous levels, because there is less MAO available to break it down, so we treat this as a do-not-combine pair. The combination has caused serotonin syndrome in case reports with other MAO inhibitors.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Red Does Rhodiola Rosea interact with ?
Rasagiline is an MAO-B inhibitor used for Parkinson's, and rhodiola appears to slow monoamine oxidase too. Stacking them could push serotonin too high, risking serotonin syndrome. We treat this as a do-not-combine pair without specialist sign-off.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Red Does SAMe interact with ?
Taking SAMe with rasagiline (an MAO-B inhibitor used for Parkinson's) can push serotonin to dangerous levels, because SAMe has its own serotonin-related activity and there is less MAO available to break it down, so we treat this as a do-not-combine pair without specialist sign-off.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Red Does Saffron Extract interact with ?
Rasagiline is an MAO-B inhibitor used for Parkinson's, and saffron has its own antidepressant effect that appears to act on serotonin. Combined, serotonin can rise too high because there is less of the enzyme available to break it down, risking serotonin syndrome. We treat this as a do-not-combine pair without specialist sign-off.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Red Does St John's Wort interact with ?
Taking St John's Wort with rasagiline (an MAO-B inhibitor used for Parkinson's) can push serotonin to dangerous levels, because there is less MAO available to break it down, so we treat this as a do-not-combine pair.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
MAOI pressor (blood-pressure surge)
Amber Does L-Tyrosine interact with ?
Taking L-Tyrosine with rasagiline can in theory raise blood pressure, because tyrosine is the raw material the body turns into noradrenaline and adrenaline and rasagiline is an MAO-B inhibitor, though the risk is lower with a selective MAO-B drug than with the older non-selective MAOIs. Raise this with your prescriber and have blood pressure checked rather than starting on your own.
Evidence: Based on an established mechanism, with no direct study of this exact combination yet.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Additive sympathomimetic activity
Amber Does Yohimbe interact with ?
Yohimbe raises blood pressure and noradrenaline. Combined with rasagiline (a Parkinson's MAO-B inhibitor), it can push blood pressure unpredictably high. We would not recommend combining without specialist supervision.
Evidence: Limited human data, based on case reports and a known mechanism.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.
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