Supplements and Propranolol hydrochloride.
Propranolol hydrochloride, sold under the brand names Inderal, Inderal-LA, Bedranol SR, Half Inderal LA, is a beta-blocker: it reduces heart rate and cardiac output by antagonising beta-adrenergic receptors.
Propranolol is a beta-blocker that blocks both beta-1 and beta-2 receptors. UK prescribing is most often for performance anxiety, essential tremor, migraine prophylaxis, and some hyperthyroid symptom control. The dual receptor action is the defining feature. It makes propranolol a stronger anxiolytic than bisoprolol for situational anxiety, but it carries higher bronchospasm risk in anyone with asthma. Propranolol is heavily metabolised by CYP1A2 and CYP2D6, so smoking (which induces CYP1A2) and certain antidepressants change its exposure. The supplement signal is smaller than for the cardio selective agents in the class, because the typical propranolol patient is on intermittent low doses for tremor or anxiety rather than chronic daily dosing. Magnesium for migraine prophylaxis is the most common supplement to see alongside. It has its own evidence base (Cochrane 2015) and combines without clinical interaction. CoQ10 for migraine prophylaxis shows a similar pattern.
We have not yet completed an explicit assessment of supplement interactions with Propranolol hydrochloride in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Propranolol hydrochloride alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How we grade severity, choose what's in scope, and what we exclude.
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The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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