Medication · beta blocker

Supplements and Propranolol hydrochloride.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Propranolol hydrochloride, sold under the brand names Inderal, Inderal-LA, Bedranol SR, Half Inderal LA, is a beta-blocker: it reduces heart rate and cardiac output by antagonising beta-adrenergic receptors.

Propranolol is a beta-blocker that blocks both beta-1 and beta-2 receptors. UK prescribing is most often for performance anxiety, essential tremor, migraine prophylaxis, and some hyperthyroid symptom control. The dual receptor action is the defining feature. It makes propranolol a stronger anxiolytic than bisoprolol for situational anxiety, but it carries higher bronchospasm risk in anyone with asthma. Propranolol is heavily metabolised by CYP1A2 and CYP2D6, so smoking (which induces CYP1A2) and certain antidepressants change its exposure. The supplement signal is smaller than for the cardio selective agents in the class, because the typical propranolol patient is on intermittent low doses for tremor or anxiety rather than chronic daily dosing. Magnesium for migraine prophylaxis is the most common supplement to see alongside. It has its own evidence base (Cochrane 2015) and combines without clinical interaction. CoQ10 for migraine prophylaxis shows a similar pattern.

We have not yet completed an explicit assessment of supplement interactions with Propranolol hydrochloride in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Propranolol hydrochloride alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Your whole stack

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This page checks the pairs you enter. The personalised Distil report goes further:

the same graded, cited interaction check across your whole stack, not just the pairs you thought to type in
where your current routine may be leaving you short of your goals
the evidence-backed compounds worth adding, and the ones worth dropping

It's a paid report: £79, or £49 for the first 25 customers. The interactions check is one section of it, and you can read a real one in full before you buy.

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Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.