Medication · hrt progesterone

Supplements and Progesterone (micronised).

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Progesterone (micronised), sold under the brand names Utrogestan, Cyclogest, is hormone replacement therapy (progesterone component).

Progesterone (micronised) is hormone replacement therapy (the progesterone component). It is prescribed alongside oestrogen in women with an intact uterus, to oppose endometrial hyperplasia driven by oestrogen. Micronised progesterone (Utrogestan) has replaced earlier synthetic progestogens in much of UK practice, given the better metabolic and breast cancer risk profile. Mechanism is GABA-A receptor modulation in addition to progesterone receptor activity. That is why bedtime dosing is standard; the sedating effect is useful. The supplement surface is small. Progesterone is metabolised by CYP3A4 but the dose is much lower than the oestrogen counterpart. The clinical signal from supplement interactions is correspondingly quieter. Symptom relief supplements (black cohosh, ashwagandha for sleep, magnesium glycinate for waking in the night) sit on top of HRT without strong interaction signals. The clinically important point is differentiating HRT progesterone use from progestogen as a contraceptive. Different agents, different goals, different dosing.

We have not yet completed an explicit assessment of supplement interactions with Progesterone (micronised) in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Progesterone (micronised) alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.