Does Vitex interact with Progesterone (micronised)?

Medication · hrt progesterone

Supplements and Progesterone (micronised).

Every documented pair, every citation. Below: 1 documented pair grouped by mechanism.

Progesterone (micronised), sold under the brand names Utrogestan, Cyclogest, Prometrium, is hormone replacement therapy (progesterone component).

Progesterone (micronised) is hormone replacement therapy (the progesterone component). It is prescribed alongside oestrogen in women with an intact uterus, to oppose endometrial hyperplasia driven by oestrogen. Micronised progesterone (Utrogestan) has replaced earlier synthetic progestogens in much of UK practice, given the better metabolic and breast cancer risk profile. Mechanism is GABA-A receptor modulation in addition to progesterone receptor activity. That is why bedtime dosing is standard; the sedating effect is useful. The supplement surface is small. Progesterone is metabolised by CYP3A4 but the dose is much lower than the oestrogen counterpart. The clinical signal from supplement interactions is correspondingly quieter. Symptom relief supplements (black cohosh, ashwagandha for sleep, magnesium glycinate for waking in the night) sit on top of HRT without strong interaction signals. The clinically important point is differentiating HRT progesterone use from progestogen as a contraceptive. Different agents, different goals, different dosing.

Below are the 1 documented pair we have explicitly assessed against Progesterone (micronised) in the Distil database: 1 amber. The pairs cluster around 1 mechanism: Hormonal axis modulation. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Last reviewed 17 June 2026. Each interaction below is assessed against PubMed-indexed evidence.

Hormonal axis modulation

Amber Does Vitex interact with ?

Vitex (chasteberry) acts on the body's hormone signals: it lowers prolactin and, in lab studies, gently nudges oestrogen and progesterone receptors. Micronised progesterone is a progesterone hormone medicine (often part of HRT), so in theory vitex could pull against its hormonal effect. There is no study showing this actually happens, so it is a caution rather than a firm warning. If you take this medicine, it is worth mentioning vitex to your prescriber before adding it.

Evidence: Based on an established mechanism, with no direct study of this exact combination yet.

PMID 7890021 · PMID 14974442 · PMID 18204102 · PMID 39519010 · BNF: Progesterone

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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