Medication · ace inhibitor

Supplements and Perindopril erbumine.

Every documented pair, every citation. Below: 2 documented pairs grouped by mechanism.

Perindopril erbumine, sold under the brand name Coversyl, is an ACE inhibitor: it lowers blood pressure by blocking the conversion of angiotensin I to angiotensin II.

Perindopril erbumine is an ACE inhibitor. The class blocks the conversion of angiotensin I to angiotensin II, dropping blood pressure and reducing afterload on the heart. The defining side effect is a dry persistent cough from bradykinin accumulation. It affects around 10 to 15 percent of UK patients and is the most common reason for switching to an ARB. Renal function depends on renin-angiotensin signalling for glomerular filtration pressure, so annual U&E checks are standard. The most clinically important class interaction with supplements is with chronic NSAID use, which blunts the antihypertensive effect and adds renal stress in older patients. Additive BP supplements (beetroot extract, hibiscus, garlic, CoQ10 at the larger studied doses) stack on top, sometimes usefully. Liquorice opposes the BP effect through aldosterone-mediated sodium retention. It warrants caution at habitual intake.

Below are the 2 documented pairs we have explicitly assessed against Perindopril erbumine in the Distil database: 1 red and 1 amber. The pairs cluster around 2 mechanisms: Additive hyperkalaemia (raised potassium) and Reduced renal lithium clearance. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.

Documented interactions

Additive hyperkalaemia (raised potassium)

Red Potassium

Perindopril raises blood potassium by reducing how much the kidneys pass out. A potassium supplement adds more potassium on top. Together they can push potassium high enough to affect the heart rhythm, which can be dangerous. Do not take a potassium supplement alongside perindopril unless your GP has specifically advised it and is checking your blood potassium.

PMID 21438068 · PMID 31800080 · BNF: Perindopril

Reduced renal lithium clearance

Amber Lithium Orotate

ACE inhibitor blood pressure tablets such as perindopril can reduce how well the kidneys clear lithium, which raises the lithium level in the blood. With prescription lithium this is a recognised caution, especially in older people. At the small amount of lithium in a typical lithium orotate supplement (around 5 mg) the effect is expected to be very small; it matters more for higher-strength products (around 20 mg) and for anyone whose kidney function is reduced. If you take an ACE inhibitor, check with your pharmacist or GP before using a lithium supplement.

PMID 8521679 · PMID 8354016 · PMID 34146638 · PMID 18072162 · BNF: Lithium

Reviewer-flagged: awaiting clinical-reviewer sign-off.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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