Medication · antipsychotic

Supplements and Olanzapine.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Olanzapine, sold under the brand names Zyprexa, ZypAdhera, is an antipsychotic: it antagonises dopamine D2 receptors and (for atypicals) serotonin receptors.

Olanzapine is an antipsychotic medicine. The class divides into typicals (haloperidol, chlorpromazine, older agents) and atypicals (olanzapine, quetiapine, risperidone, aripiprazole, the newer agents). Both block dopamine D2 receptors. The atypicals add 5-HT2 receptor blockade and a different side effect profile. Most UK community prescribing is atypicals. The supplement surface includes three patterns: additive sedation (especially with quetiapine), QT prolongation (haloperidol, ziprasidone, some others), and CYP interactions for the more 3A4-sensitive agents in the class. Metabolic side effects (weight gain, glucose dysregulation, lipid effects) underpin the routine monitoring that NICE NG178 recommends. St John's Wort is flagged by the BNF across the class given enzyme induction concerns. Specific supplements with the closest serotonergic overlap (5-HTP, SAMe at high dose, saffron extract) warrant care, particularly alongside atypicals with significant 5-HT2 activity.

We have not yet completed an explicit assessment of supplement interactions with Olanzapine in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Olanzapine alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

Anything we should know? (optional)

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Your supplements

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Your medications

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How we decide

How we grade severity, choose what's in scope, and what we exclude.

Every call on this page is reasoned. We publish the full rubric for severity tiers, the medication inclusion logic, the evidence grades we accept, and what we deliberately leave out. About three thousand words. Worth reading once if you use this tool more than occasionally.

Read the full methodology

Something missing?

If a supplement or medication you take isn't in our autocomplete, tell us. We go through what people flag every week and add what's missing.

Thanks, that's logged. We go through flagged items every week.

Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.