Medication · antispasmodic gi

Supplements and Mebeverine hydrochloride.

Not yet catalogued in the Distil interactions database. We surface that distinction explicitly.

Mebeverine hydrochloride, sold under the brand names Colofac, Colofac IBS, Colofac MR, Aurobeverine MR, is a gastrointestinal antispasmodic: it relaxes smooth muscle in the gut wall.

Mebeverine hydrochloride is a gastrointestinal antispasmodic. It is prescribed for irritable bowel syndrome and similar functional gut conditions. The class includes mebeverine, hyoscine, alverine, and peppermint oil. Mechanism varies. Anticholinergic (hyoscine). Direct smooth muscle relaxation (mebeverine). Or calcium channel modulation (peppermint oil). The supplement surface is small because the agents have minimal CYP metabolism. Anticholinergic burden matters most when antispasmodics like hyoscine are combined with other anticholinergic medicines or supplements. Older patients are most sensitive. Peppermint oil enteric-coated capsules count as a supplement in their own right, and have a modest evidence base for IBS symptom relief; Cochrane reviews place the effect size as small but real. Anyone combining a prescribed antispasmodic with peppermint oil should ideally do so on advice rather than randomly.

We have not yet completed an explicit assessment of supplement interactions with Mebeverine hydrochloride in the Distil database. That is different from saying nothing exists. We surface this distinction deliberately: the Distil checker tells you when we have explicitly assessed a pair and when we have not, because both are useful information. If you take Mebeverine hydrochloride alongside a supplement, the checker below will surface anything already in our database, and the missing-item form at the bottom of the page routes uncatalogued pairs into our next curation pass.

What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.

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For adults over 18. This tool gives evidence-graded information, not medical advice. Always discuss changes with your GP, especially if you take any medication, are pregnant, breastfeeding, or have a serious health condition.

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How we grade severity, choose what's in scope, and what we exclude.

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Distil's interactions database is reviewed and updated every quarter. We grade evidence transparently and publish our methodology, including every database change, at /about/methodology. This tool is information, not a substitute for clinical judgement. If you take medication and supplements together, your GP or pharmacist can review your full regimen against your medical history. If you want a full personalised stack reasoned against this same database, the Distil report is the next step up.