Supplements and Lisinopril.
Lisinopril, sold under the brand names Zestril, Carace, Prinivil, is an ACE inhibitor: it lowers blood pressure by blocking the conversion of angiotensin I to angiotensin II.
Lisinopril is the second most prescribed ACE inhibitor in England after ramipril. It blocks the same target as ramipril, with a slightly longer plasma half life. The clinical and supplement profiles mirror ramipril almost exactly. Dry cough in 10 to 15 percent of patients (the most common reason for switching to an ARB). Annual U&E monitoring. Additive blood pressure interactions with the nitrate pathway supplements (beetroot, hibiscus, garlic). CoQ10 lowers systolic pressure by about 5 mmHg in people with cardiometabolic conditions (Zhao 2022), though a Cochrane review of two small trials found no significant effect in primary hypertension and no study has tested it alongside a blood-pressure drug, so watch readings rather than treat it as a known interaction. The NSAID interaction is the most clinically important. Chronic ibuprofen or naproxen blunts the antihypertensive effect of lisinopril and adds renal stress, especially in older patients with already borderline GFR. Supplements that shift potassium warrant care. Liquorice taken at high intake opposes the BP effect via sodium retention. Potassium-rich supplements can push potassium higher than the GP intended, particularly if the patient is also on a potassium-sparing diuretic.
Below are the 7 documented pairs we have explicitly assessed against Lisinopril in the Distil database: 1 severe and 6 caution. The pairs cluster around 3 mechanisms: Additive hyperkalaemia (raised potassium), Additive blood-pressure lowering, and Reduced renal lithium clearance. Every call is cited to either a clinical reference (PMID) or the British National Formulary. Anything not on this list is either still to be assessed or beyond our database scope. The checker beneath surfaces assessments by supplement, and the missing-item form at the bottom of the page routes any uncatalogued supplement into our next curation pass.
Documented interactions
Last reviewed 14 June 2026. Each interaction below lists the evidence its assessment drew on: some rest on studies of the exact pair, others on mechanism evidence, where a citation may support one part of the reasoning rather than the exact combination. The evidence line on each entry says which.
Additive hyperkalaemia (raised potassium)
Severe Does Potassium interact with Lisinopril?
Lisinopril raises blood potassium by reducing how much the kidneys pass out. A potassium supplement adds more potassium on top. Together they can push potassium high enough to affect the heart rhythm, which can be dangerous. Do not take a potassium supplement alongside lisinopril unless your GP has specifically advised it and is checking your blood potassium.
Evidence: Supported by human study data.
Additive blood-pressure lowering
Caution Does Beetroot Extract interact with Lisinopril?
Beetroot lowers blood pressure through the nitric oxide pathway. Lisinopril lowers it by blocking the angiotensin-converting enzyme. Used together, the combined blood-pressure effect tends to be larger than either alone. Watch for dizziness on standing, especially in the first two weeks. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Caution Does Hibiscus Extract interact with Lisinopril?
Hibiscus tends to lower blood pressure on its own, and lisinopril lowers it by blocking the angiotensin-converting enzyme. Taken together the blood-pressure effects may stack, so watch for dizziness on standing, especially in the first couple of weeks. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does L-Citrulline interact with Lisinopril?
L-citrulline lowers blood pressure modestly through the nitric oxide pathway, and lisinopril lowers blood pressure by blocking the renin-angiotensin system. Used together, the combined blood-pressure effect is mild but real. Watch for dizziness on standing, especially in the first two weeks. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Caution Does Spirulina interact with Lisinopril?
Spirulina has a mild blood-pressure-lowering effect of its own, shown in human trials. Lisinopril lowers blood pressure by blocking the angiotensin-converting enzyme. Used together, the combined effect tends to be a little larger than the medicine alone. Watch for dizziness on standing in the first couple of weeks, and tell your GP if it happens so your dose can be reviewed.
Evidence: Limited human data, from small studies or case reports.
Caution Does Taurine interact with Lisinopril?
Taurine tends to lower blood pressure on its own, and lisinopril lowers it by blocking the angiotensin-converting enzyme. Taken together the blood-pressure effects may stack, so watch for dizziness on standing, especially in the first couple of weeks. Taurine's own effect on blood pressure is small. If symptoms appear, tell your GP.
Evidence: Limited human data, from small studies or case reports.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
Reduced renal lithium clearance
Caution Does Lithium Orotate interact with Lisinopril?
ACE inhibitor blood pressure tablets such as lisinopril can reduce how well the kidneys clear lithium, which raises the lithium level in the blood. With prescription lithium this is a recognised caution, especially in older people. At the small amount of lithium in a typical lithium orotate supplement (around 5 mg) the effect is expected to be very small; it matters more for higher-strength products (around 20 mg) and for anyone whose kidney function is reduced. If you take an ACE inhibitor, check with your pharmacist or GP before using a lithium supplement.
Evidence: No direct study of this exact combination yet; the caution rests on a plausible mechanism or on reports involving a related medicine.
Reviewer-flagged: awaiting clinical-reviewer sign-off.
What this list does not say. Pairs not flagged here are not implicitly safe. They are either not yet in our database, or fall outside our inclusion scope (food-supplement interactions only; for drug-drug interactions, the BNF is authoritative). Use the checker below to surface any supplement, and submit a missing item if you take something we have not catalogued.
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How the checker decides
Every result has a source
Each pair we have assessed is cited to a published study (PMID) or the British National Formulary, so you can read the source yourself.
Four kinds of answer
Severe, caution, no known interaction, and not yet assessed. A pair we have not assessed is never shown as clear.
- Severe
- Caution
- No known interaction
- Not yet assessed
Nothing in our data is not a clearance
When nothing in our data records a problem with a pair, the result says no known interaction at typical doses, which is not a clearance: your pharmacist or GP can check the pair against your full medical history.
A full supplement review, built around you, not a generic stack.
The free checker answers one interaction question at a time. A Distil report reviews the bigger picture: your goals, diet, medications, current supplements and any blood results you provide, then shows what appears worth keeping, changing, adding or leaving out.
- what your diet already covers, so you are not adding a capsule for something food is already handling
- which evidence-graded compounds are worth considering for your goals, and which were considered but left out
- what to keep, change or stop from what you already take, plus the order to introduce anything new
- how your medications and complete supplement stack fit together, with daily timing and a clear point for reassessment
The interaction check is one section of the full report. You also get the reasoning behind each recommendation and the evidence references used.
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